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New treatment option for Obstructive Sleep Apnea
Official title Identification of Biomarkers of Obstructive Sleep Apnea.
ClinicalTrials.gov ID: NCT07723144
What this study is testing
- What it's testing
- Obstructive sleep apnea (OSA) is a common sleep disorder associated with intermittent hypoxia, systemic inflammation, oxidative stress, and an increased risk of cardiovascular and metabolic diseases. Current diagnostic methods are effective but have limited availability and do not adequately predict disease burden or treatment response.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 65. Healthy volunteers may be eligible.
You may be able to join if
- Participants with obstructive sleep apnea (OSA):
- Age 18 to 65 years.
- Moderate or severe obstructive sleep apnea confirmed by overnight polysomnography (apnea-hypopnea index [AHI] ≥15 events/hour).
- Willing and able to provide written informed consent.
- Willing to undergo repeated blood sampling and study assessments.
You likely can't join if
- Mild obstructive sleep apnea (AHI 5 to \<15 events/hour).
- Central sleep apnea.
- Previous treatment for obstructive sleep apnea within the previous 3 months.
- Body mass index (BMI) ≥40 kg/m².
- Severe cardiovascular disease.
- Severe kidney disease or impaired renal function.
See the full eligibility criteria
- Participants with obstructive sleep apnea (OSA):
- Age 18 to 65 years.
- Moderate or severe obstructive sleep apnea confirmed by overnight polysomnography (apnea-hypopnea index [AHI] ≥15 events/hour).
- Willing and able to provide written informed consent.
- Willing to undergo repeated blood sampling and study assessments.
- Willing to use positive airway pressure (PAP) therapy and accept random assignment to immediate or delayed treatment.
- Control participants:
- Age 18 to 65 years.
- No obstructive sleep apnea (AHI \<5 events/hour on overnight polysomnography).
- Willing and able to provide written informed consent.
- Willing to undergo study assessments and blood sampling.
- Mild obstructive sleep apnea (AHI 5 to \<15 events/hour).
- Central sleep apnea.
- Previous treatment for obstructive sleep apnea within the previous 3 months.
- Body mass index (BMI) ≥40 kg/m².
- Severe cardiovascular disease.
- Severe kidney disease or impaired renal function.
- Significant liver disease.
- Chronic inflammatory, autoimmune, or rheumatic disease.
- Active cancer or other condition associated with systemic inflammation.
- Chronic respiratory diseases, including asthma or chronic obstructive pulmonary disease.
- Respiratory infection within 4 weeks before enrollment.
- Major surgery or significant injury within the previous 3 months.
- Chronic rhinosinusitis.
- Current treatment with systemic corticosteroids, immunosuppressive drugs, cytotoxic drugs, chronic anti-inflammatory medications, or other medications that may influence inflammatory biomarkers.
- Pregnancy or any condition that, in the opinion of the investigators, would make participation unsafe or interfere with interpretation of the study results.
The study team makes the final eligibility decision.
Where it's taking place
- Bialystok, Podlaskie Voivodeship, Poland
Compensation & support
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 65 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Bialystok, Podlaskie Voivodeship, Poland. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.