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New treatment option for Acute Brain Injury
Official title Brain Monitoring During PEEP-Based Respiratory Therapy in Critically Ill Patients
ClinicalTrials.gov ID: NCT07716787
What this study is testing
- What it's testing
- Mechanical ventilation is commonly used in critically ill patients with acute brain injury. Positive end-expiratory pressure (PEEP) and lung recruitment maneuvers are important ventilator strategies for improving oxygenation, but they may also influence cerebral blood flow, systemic hemodynamics, carbon dioxide levels, and brain electrical activity.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Age ≥18 years.
- Admission to the neurocritical care unit with acute brain injury requiring intensive care management.
- Receiving invasive mechanical ventilation.
- Undergoing clinically indicated recruitment maneuvers and positive end-expiratory pressure (PEEP) adjustments.
- Availability of an adequate temporal acoustic window for transcranial Doppler monitoring.
You likely can't join if
- Pregnancy.
- Hemodynamic instability precluding recruitment maneuvers or PEEP adjustments.
- Severe cardiac dysfunction judged by the treating physician to contraindicate study procedures.
- Inability to obtain adequate transcranial Doppler signals.
- Conditions preventing EEG monitoring, including extensive scalp injury or dressings that preclude electrode placement.
- Withdrawal of informed consent.
See the full eligibility criteria
- Age ≥18 years.
- Admission to the neurocritical care unit with acute brain injury requiring intensive care management.
- Receiving invasive mechanical ventilation.
- Undergoing clinically indicated recruitment maneuvers and positive end-expiratory pressure (PEEP) adjustments.
- Availability of an adequate temporal acoustic window for transcranial Doppler monitoring.
- Written informed consent obtained from the participant or a legally authorized representative.
- Pregnancy.
- Hemodynamic instability precluding recruitment maneuvers or PEEP adjustments.
- Severe cardiac dysfunction judged by the treating physician to contraindicate study procedures.
- Inability to obtain adequate transcranial Doppler signals.
- Conditions preventing EEG monitoring, including extensive scalp injury or dressings that preclude electrode placement.
- Withdrawal of informed consent.
The study team makes the final eligibility decision.
Where it's taking place
- Dongying, Shandong, China
Compensation & support
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Dongying, Shandong, China. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.