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Official title Effects of Acute Ketone Supplementation on the Brain
ClinicalTrials.gov ID: NCT07711990
What this study is testing
- What it's testing
- The purpose of this study is to determine how a ketone ester supplement affects brain function, brain blood flow, and brain metabolism in healthy middle-aged and older adults. Ketones are naturally produced by the body during periods of fasting or carbohydrate restriction and serve as an alternative fuel source for the brain.
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance. You may not know which one you got.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 45 to 65. Healthy volunteers may be eligible.
You may be able to join if
- Age ≥45 years and ≤65 years
- Able to comply with study requirements including presenting for each test session following an overnight fast and not following a ketogenic diet...
- BMI between 18.5 and 30 kg/m2
You likely can't join if
- Non-English Speaking
- Currently taking a ketone ester supplement, ketone salt supplement, or on a ketogenic diet
- Pregnancy, a urine pregnancy test will be given to all women before scanning to confirm nonpregnant status
- Currently breastfeeding
- Allergies to components in the test products, including milk protein, and not lactose intolerant
- History of high blood pressure
See the full eligibility criteria
- Age ≥45 years and ≤65 years
- Able to comply with study requirements including presenting for each test session following an overnight fast and not following a ketogenic diet during the duration of the study.
- BMI between 18.5 and 30 kg/m2
- Non-English Speaking
- Currently taking a ketone ester supplement, ketone salt supplement, or on a ketogenic diet
- Pregnancy, a urine pregnancy test will be given to all women before scanning to confirm nonpregnant status
- Currently breastfeeding
- Allergies to components in the test products, including milk protein, and not lactose intolerant
- History of high blood pressure
- History of alcoholism (previous 2 years)
- History of illicit drug use
- History of head trauma involving loss of consciousness or skull fracture
- Diagnosed neurological disease
- Taking psychiatric prescriptive medications (antipsychotics, antidepressants, or barbiturates) or over-the-counter (OTC) medications (other than those taken as nutritional supplements for non-therapeutic indications)
- Current smoker
- Currently consuming a habitual ketogenic diet, or was consuming a habitual ketogenic diet in the past three months
- Any condition or material in the body that is a contraindication for MRI procedures
The study team makes the final eligibility decision.
Where it's taking place
- Columbus, Ohio, United States
Compensation & support
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 45 years to 65 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Columbus, Ohio, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.