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New treatment option for NSCLC (Non-small Cell Lung Cancer)
Official title Pralsetinib DDI Study in Patients With Advanced or Metastatic Solid Tumors
ClinicalTrials.gov ID: NCT07704658
What this study is testing
What is Pralsetinib?
Pralsetinib is an investigational medicine, given as an once-daily pill taken by mouth, being studied as a potential treatment for nsclc (non-small cell lung cancer).
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- An open-label drug-drug interaction study to evaluate the effects of pralsetinib (Gavreto) on the pharmacokinetics of a CYP450 probe substrate cocktail and, in female participants, a hormonal probe substrate, in participants with rearranged during transfection (RET) fusion- or mutation-positive solid tumors
- Phase 4: studies an already-approved treatment
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Must be willing and able to participate and comply with all study requirements and to provide signed and dated written informed consent
- Adult male or female ≥ 18 years of age at the time of signing the informed consent form.
- Must have a body mass index (BMI) ≥ 18 and ≤ 32 kg/m² and a minimum body weight of 50 kg at screening.
- Must have an Eastern Cooperative Oncology Group performance status ≤ 2.
- Must have recovered from the non-hematologic toxic effects of prior treatment to Grade ≤ 1, or baseline value (excluding infertility, alopecia, or...
You likely can't join if
- Clinically relevant abnormal medical history, abnormal findings on physical examination, vital signs, electrocardiogram (ECG), or laboratory tests at...
- Surgery (e.g., gastric bypass) or medical condition that may significantly affect absorption of study medications, as judged by the investigator.
- History of pneumonitis within the last 12 months.
- History of active or latent tuberculosis (TB), regardless of treatment history, or a positive screening test for latent Mycobacterium tuberculosis...
- Serious infection requiring intravenous or systemic antibiotics within 7 days prior to initiation of study treatment, or any active infection that...
- Clinically significant, uncontrolled cardiovascular disease, including:
See the full eligibility criteria
Who can join
- Must be willing and able to participate and comply with all study requirements and to provide signed and dated written informed consent
- Adult male or female ≥ 18 years of age at the time of signing the informed consent form.
- Must have a body mass index (BMI) ≥ 18 and ≤ 32 kg/m² and a minimum body weight of 50 kg at screening.
- Must have an Eastern Cooperative Oncology Group performance status ≤ 2.
- Must have recovered from the non-hematologic toxic effects of prior treatment to Grade ≤ 1, or baseline value (excluding infertility, alopecia, or Grade 1 neuropathy)
- Must have a confirmed diagnosis of advanced or metastatic solid tumor that has relapsed after, or is not responsive to, standard therapies and harbors an oncogenic RET fusion or mutation as determined by a validated...
- Must have adequate organ function, defined by the following:
- Absolute neutrophil count (ANC) ≥ 1.0 × 10⁹/L.
- Platelet count ≥ 75 × 10⁹/L.
- Hemoglobin ≥ 9 g/dL.
- Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤ 3 × upper limit of normal (ULN), or ≤ 5 × ULN in patients with known liver metastases.
- Total bilirubin ≤ 1.5 × ULN (≤ 3 × ULN in patients with Gilbert syndrome).
- Creatinine clearance ≥ 40 mL/min using the Cockcroft-Gault equation.
- Serum phosphorus ≤ 5.5 mg/dL.
- International normalized ratio (INR), prothrombin time (PT), and activated partial thromboplastin time (aPTT) within normal laboratory limits.
- Must be at least 4 weeks from major surgery, radiotherapy, chemotherapy, immunotherapy, kinase/targeted therapy, or gene therapy prior to the first dose of study treatment and recovered from treatment-related toxicities...
- Female patients may participate if they are not of childbearing potential (e.g., surgically sterile or postmenopausal).
- Male patients with female partners of childbearing potential must agree to use highly effective contraception during study treatment and for 90 days after the last dose of study treatment.
- Male patients must refrain from sperm donation during study treatment and for 90 days after the last dose of study treatment.
What rules you out
- Clinically relevant abnormal medical history, abnormal findings on physical examination, vital signs, electrocardiogram (ECG), or laboratory tests at screening that, in the investigator's judgment, are likely to...
- Surgery (e.g., gastric bypass) or medical condition that may significantly affect absorption of study medications, as judged by the investigator.
- History of pneumonitis within the last 12 months.
- History of active or latent tuberculosis (TB), regardless of treatment history, or a positive screening test for latent Mycobacterium tuberculosis infection by QuantiFERON® TB Gold. Indeterminate results may be...
- Serious infection requiring intravenous or systemic antibiotics within 7 days prior to initiation of study treatment, or any active infection that, in the opinion of the investigator, could impact patient safety (e.g...
- Clinically significant, uncontrolled cardiovascular disease, including:
- New York Heart Association (NYHA) Class III or IV congestive heart failure.
- Myocardial infarction or unstable angina within the previous 6 months, clinically significant uncontrolled arrhythmias, including bradyarrhythmias that may cause QT prolongation (e.g., second- or third-degree heart...
- Uncontrolled hypertension (i.e., mean systolic blood pressure ≥180 mmHg and/or diastolic blood pressure ≥110 mmHg on 3 repeated measurements) or clinically significant hypotension (i.e., systolic blood pressure \<90...
- History of prolonged QT syndrome or torsades de pointes, or familial history of long QT syndrome.
- QTcF ≥470 ms on at least 2 ECGs performed \>30 minutes apart.
- Central nervous system (CNS) metastases or primary CNS tumor.
- Use of systemic corticosteroids within 4 weeks prior to first dose of study treatment.
- More than 30 Gy of radiotherapy to the lung within 6 months prior to check-in.
- History of multiple and/or severe allergies to drugs or foods, or history of severe anaphylactic reaction.
- Use of prohibited medications or procedures
- Medical conditions, treatments, or underlying diseases that constitute contraindications to the use of study substrates or probe drugs
- Ingestion of alcohol within 72 hours prior to first study drug administration and during the study period.
- Participation in another investigational drug trial within 30 days prior to study drug administration (or within 5 half-lives of the investigational drug, whichever is longer) or exposure to more than 3 investigational...
- Positive serology for hepatitis B surface antigen (HBsAg) or hepatitis C virus (HCV) antibody at screening (a negative PCR test overrides a positive serology).
- Positive human immunodeficiency virus (HIV) test at screening.
- Positive urine drug screen (unless attributable to concomitant medication) or positive alcohol breath test at screening and/or Day -1.
- Patients who are legally incapacitated, have limited legal capacity, or are otherwise considered vulnerable.
- Female patients who are pregnant or breastfeeding.
- Patients who plan to become pregnant or father a child (including ova or sperm donation) during the study or within 3 months after the last dose of study drug.
- Known allergy or history of hypersensitivity to study drug(s) or their excipients.
- Concomitant use of strong or moderate CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, and/or CYP3A4 inhibitors within 7 days or 5 half-lives (whichever is longer) prior to first dose of study treatment.
- Concomitant use of strong or moderate CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, and/or CYP3A4 inducers within 14 days or 5 half-lives (whichever is longer) prior to first dose of study treatment.
- History of or active clinically significant cardiovascular, respiratory, gastrointestinal, renal, hepatic, neurological, psychiatric, musculoskeletal, genitourinary, dermatologic, hematologic, or other disorder that, in...
- History of prior second malignancy unless disease-free for ≥ 12 months or considered surgically cured. Patients with nonmelanoma skin cancers or with carcinomas in situ at any time following curative intent surgery and...
The study team makes the final eligibility decision.
Where it's taking place
- Logroño, La Rioja, Spain
- Madrid, Spain
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Logroño, La Rioja, Spain; Madrid, Spain. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.