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Compares treatment options for ICU Acquired Weakness
Official title ICU CONNECT: Study Comparing EMG in Healthy Volunteers and ICU Patients.
ClinicalTrials.gov ID: NCT07699562
What this study is testing
- What it's testing
- This study is testing whether a non-invasive nerve monitoring device (TetraGraph) can accurately detect early signs of ICU-acquired weakness by comparing readings from the device with standard nerve conduction/EMG tests done by a specialist to see if they match. They will focus on muscle response signals in the hand and leg over about 10 days in three groups: healthy volunteers, ICU patients who are not on ventilators, and ICU patients who are on ventilators.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 90. Healthy volunteers may be eligible.
You may be able to join if
- Cohort 1: Healthy volunteers
- people must be \> 18 years old and \< 90 years old.
- people must consent to participate. Cohort 2: Non-intubated critically ill patients
- people may be male or female.
- people must be \> 18 years old and \< 90 years old.
You likely can't join if
- Cohort 1: Healthy volunteers Exclusion criteria:
- people with previous paralysis or neuromuscular disease.
- people with spinal cord or brain injuries that impact motor function.
- people with an allergy to clinical adhesive or hydrogel. Cohort 2: Non-intubated critically ill patients Exclusion criteria:
- people with previous paralysis or neuromuscular diseases.
- people with previous peripheral nerve injuries to the tested limbs.
See the full eligibility criteria
- Cohort 1: Healthy volunteers
- people must be \> 18 years old and \< 90 years old.
- people must consent to participate. Cohort 2: Non-intubated critically ill patients
- people may be male or female.
- people must be \> 18 years old and \< 90 years old.
- people must have a POA or next of kin who is able to consent (for those in the ICU and who are unable to consent themselves). Cohort 3: Intubated critically ill patients
- people may be male or female.
- people must be \> 18 years old and \< 90 years old.
- people must have a POA or next of kin who is able to consent (for those in the ICU and who are unable to consent themselves).
- For the people in the ICU that are intubated, they must be planned to be intubated for at least 24 hours.
- people must be intubated for no longer than ≥ 72 hours before enrollment.
- Cohort 1: Healthy volunteers Exclusion criteria:
- people with previous paralysis or neuromuscular disease.
- people with spinal cord or brain injuries that impact motor function.
- people with an allergy to clinical adhesive or hydrogel. Cohort 2: Non-intubated critically ill patients Exclusion criteria:
- people with previous paralysis or neuromuscular diseases.
- people with previous peripheral nerve injuries to the tested limbs.
- people with spinal cord or brain injuries (including stroke) that impact motor function.
- people without a POA or next of kin for those patients that are unable to consent themselves.
- people with an allergy to clinical adhesive or hydrogel. Cohort 3: Intubated critically ill patients Exclusion criteria:
- people with previous paralysis or neuromuscular disease
- people with previous peripheral nerve injuries to the tested limbs.
- people with spinal cord or brain injuries that impact motor function.
- people without a POA or next of kin for those patients that are in the intubated arm.
- people with intubations expected to last less than 24 hours.
- people who have already been intubated for \> 72 hours.
- people with an allergy to clinical adhesive or hydrogel.
The study team makes the final eligibility decision.
Where it's taking place
- Evanston, Illinois, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 90 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Evanston, Illinois, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.