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Prevention study for Cancer (Solid Tumors)
Official title Steroid Sparing Regimen With Olanzapine and Palonosetron for Emetic Prevention for High Dose Cisplatin
ClinicalTrials.gov ID: NCT07699276
What this study is testing
What is dexamethasone sparing?
dexamethasone sparing is an investigational medicine, being studied as a potential treatment for cancer (solid tumors).
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- A phase II study evaluating dexamethasone sparing regimen with olanzapine and palonosetron for patients receiving high dose cisplatin to prevent chemotherapy induced nausea and vomiting
- Phase 2: a mid-size study of how well it works
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- histologically confirmed solid malignancy
- scheduled for first cycle of cisplatin at dosage of at least 50 mg/m2
You likely can't join if
- pregnancy
- pelvic or abdominal radiation within 4 weeks
- uncontrolled brain metastasis
- other moderate or high emetic risk chemotherapy on day 2-5
- untreated gut obstruction
- known allergy or severe adverse effect from palonosetron or olanzapine
See the full eligibility criteria
- histologically confirmed solid malignancy
- scheduled for first cycle of cisplatin at dosage of at least 50 mg/m2
- pregnancy
- pelvic or abdominal radiation within 4 weeks
- uncontrolled brain metastasis
- other moderate or high emetic risk chemotherapy on day 2-5
- untreated gut obstruction
- known allergy or severe adverse effect from palonosetron or olanzapine
- AST/ ALT \> 2.5x or serum creatinine clearance less than 50 ml/min
The study team makes the final eligibility decision.
Where it's taking place
- Bangkok, Thailand
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Bangkok, Thailand. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.