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New treatment option for Major Depressive Disorder (MDD)
Official title Cannabidiol Oil for Treatment-Resistant Major Depression
ClinicalTrials.gov ID: NCT07696871
What this study is testing
What is Full-spectrum CBD oil 100 mg/mL?
Full-spectrum CBD oil 100 mg/mL is an investigational medicine, being studied as a potential treatment for major depressive disorder (mdd).
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Major depressive disorder is one of the leading causes of disability worldwide, and a substantial proportion of patients do not achieve adequate improvement with conventional antidepressant treatments. Cannabidiol (CBD), a non-intoxicating cannabinoid derived from Cannabis sativa, has shown potential anxiolytic, anti-inflammatory, and neurobiological effects that may be relevant for depressive disorders.
- Phase 2: a mid-size study of how well it works
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance. You may not know which one you got.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 69
You may be able to join if
- Adults aged 18 to 69 years
- Diagnosis of Major Depressive Disorder (MDD)
- Persistent depressive symptoms despite ongoing antidepressant treatment
- Stable antidepressant treatment for at least four weeks before enrollment
- Residence in Brazil
You likely can't join if
- Current use of cannabis-derived products or cannabinoid-based medications
- Diagnosis of bipolar disorder, schizophrenia, or other psychotic disorders
- Current substance use disorder, except nicotine or caffeine
- Pregnancy or breastfeeding
- Severe or unstable medical conditions that may interfere with study participation
- History of hypersensitivity or allergy to Cannabis sativa products or MCT oil
See the full eligibility criteria
- Adults aged 18 to 69 years
- Diagnosis of Major Depressive Disorder (MDD)
- Persistent depressive symptoms despite ongoing antidepressant treatment
- Stable antidepressant treatment for at least four weeks before enrollment
- Residence in Brazil
- Ability to understand study procedures and comply with study requirements
- Provision of written informed consent
- Current use of cannabis-derived products or cannabinoid-based medications
- Diagnosis of bipolar disorder, schizophrenia, or other psychotic disorders
- Current substance use disorder, except nicotine or caffeine
- Pregnancy or breastfeeding
- Severe or unstable medical conditions that may interfere with study participation
- History of hypersensitivity or allergy to Cannabis sativa products or MCT oil
- Active suicidal ideation or significant suicide risk requiring immediate intervention
- Participation in another clinical trial within the previous 30 days
- Inability to comply with study procedures or follow-up assessments
The study team makes the final eligibility decision.
Where it's taking place
- Tubarão, Santa Catarina, Brazil
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 69 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Tubarão, Santa Catarina, Brazil. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.