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New treatment option for Upper Limb Amputation
Official title Microneurography and Intraneural Microstimulation for Upper Limb Sensory Investigation in Healthy and Amputee Subjects
ClinicalTrials.gov ID: NCT07691957
What this study is testing
- What it's testing
- The goal of this experimental study is to investigate the somatosensory system through intraneural recording and stimulation of the median nerve in healthy volunteers and participants with upper-limb amputation. The main questions it aims to answer are: How does median nerve activity encode tactile perception during different types of mechanical tactile stimulation in healthy subjects?
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 60. Healthy volunteers may be eligible.
You may be able to join if
- Healthy participants
- Age between 18-60 years, of any sex
- Signed informed consent
- No neurological diseases
- Presence of both intact upper limbs
You likely can't join if
- Healthy participants
- Conditions affecting perceptual abilities
- Inability to provide informed consent
- Pregnancy or breastfeeding (self-reported)
- Clinical conditions that, in the judgment of the investigator responsible for recruitment, may interfere with microneurography, microstimulation, and...
- Current or past substance abuse
See the full eligibility criteria
- Healthy participants
- Age between 18-60 years, of any sex
- Signed informed consent
- No neurological diseases
- Presence of both intact upper limbs
- Normal language, visuospatial, and general intellectual abilities, assessed using the Wechsler Adult Intelligence Scale-Revised (WAIS-R) (Appendix 1) Amputee participants
- Age between 18-60 years, of any sex
- Signed informed consent
- Upper-limb amputation (transradial or hand amputation)
- Stable amputation for at least one year
- Normal language, visuospatial, and general intellectual abilities, assessed using the Wechsler Adult Intelligence Scale-Revised (WAIS-R) (Appendix 1)
- Evidence of residual peripheral nerve function in the stump, based on nerve conduction studies as documented in clinical records
- Healthy participants
- Conditions affecting perceptual abilities
- Inability to provide informed consent
- Pregnancy or breastfeeding (self-reported)
- Clinical conditions that, in the judgment of the investigator responsible for recruitment, may interfere with microneurography, microstimulation, and EEG procedures
- Current or past substance abuse
- Brain injury with residual motor impairment
- Depression
- Presence of neurological or musculoskeletal disorders
- Diabetes mellitus
- Current or previous dermatological conditions
- Morphological nerve abnormalities, as indicated by ultrasound or MRI findings in clinical records
- Upper-limb amputation Amputee participants
- Psychological and/or cognitive disorders
- Inability to provide informed consent
- Pregnancy or breastfeeding (self-reported)
- Clinical conditions that, in the judgment of the investigator responsible for recruitment, may interfere with microneurography, microstimulation, and EEG procedures
- Current or past substance abuse
- Brain injury with residual motor impairment
- Depression
- Presence of neurological or musculoskeletal disorders
- Diabetes mellitus
- Current or previous dermatological conditions
- Morphological nerve abnormalities, as indicated by ultrasound or MRI findings in clinical records
- Bilateral upper-limb amputation
The study team makes the final eligibility decision.
Where it's taking place
- Pisa, Pisa, Italy
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 60 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Pisa, Pisa, Italy. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.