BridgeMD
New treatment option for Aphasia
Official title Superiority Trial of Aphasia-focused Rehabilitation With tDCS Stimulation
ClinicalTrials.gov ID: NCT07688551
What this study is testing
- What it's testing
- The purpose of this study is to help us understand if adding transcranial Direct Current Stimulation (tDCS), a non-invasive brain stimulation technique, to Speech Therapy improves language recovery in people with Broca's aphasia and is more effective than Speech Therapy alone.
- Phase 3: a large, late-stage study
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 25 to 80
You may be able to join if
- Be willing and able to give informed consent.
- Be willing and able to comply with study requirements.
- Be between 25 and 80 years of age.
- Have used English as the primary language for \> 15 years.
- Have the diagnosis of aphasia due to a left hemisphere stroke, confirmed by study physician based on past clinical MRI scan or research scan.
You likely can't join if
- History of brain surgery except for during the treatment of the acute stroke.
- Seizures during the previous 12-months.
- Compromised skin at or near electrode sites (e.g., rash, eczema, wounds, infection).
- Correctly name more than 140 out of 175 items during the pre-treatment picture naming test (Philadelphia Naming Test).
- Western Aphasia Battery-Revised Aphasia Quotient (WAB-R AQ) score of 25 or below.
- Participants with open skull defects (e.g., greater than 1 cm) in the area underneath the anode electrode positioning or participants with metal...
See the full eligibility criteria
- Be willing and able to give informed consent.
- Be willing and able to comply with study requirements.
- Be between 25 and 80 years of age.
- Have used English as the primary language for \> 15 years.
- Have the diagnosis of aphasia due to a left hemisphere stroke, confirmed by study physician based on past clinical MRI scan or research scan.
- Be greater than 6 months post-stroke.
- Have Broca's aphasia diagnosed by the WAB-R (fluency score ≤ 5, auditory verbal comprehension score 4-10, repetition score 0-7.9, naming and word finding score \< 9).
- Correctly name 140 or fewer items on the PNT.
- History of brain surgery except for during the treatment of the acute stroke.
- Seizures during the previous 12-months.
- Compromised skin at or near electrode sites (e.g., rash, eczema, wounds, infection).
- Correctly name more than 140 out of 175 items during the pre-treatment picture naming test (Philadelphia Naming Test).
- Western Aphasia Battery-Revised Aphasia Quotient (WAB-R AQ) score of 25 or below.
- Participants with open skull defects (e.g., greater than 1 cm) in the area underneath the anode electrode positioning or participants with metal implants or electrical stimulators.
- Participants with continuous oxygen therapy which cannot be discontinued for more than 1 hour.
- Any condition or situation that the PI determines would significantly interfere with the participant's ability to complete the study.
The study team makes the final eligibility decision.
Where it's taking place
- Charleston, South Carolina, United States
- Columbia, South Carolina, United States
- Salt Lake City, Utah, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 25 years to 80 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Charleston, South Carolina, United States; Columbia, South Carolina, United States; Salt Lake City, Utah, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.