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New treatment option for STEMI - ST Elevation Myocardial Infarction
Official title Comparative Evaluation of Sustained meChanical AsPiration Thrombectomy and no Thrombus Modification for Pre-stent Thrombus bUrden Reduction in Patients With Acute Myocardial Infarction Study: the CAPTURE AMI Study
ClinicalTrials.gov ID: NCT07687576
What this study is testing
- What it's testing
- The CAPTURE AMI trial is an investigator-initiated, single-centre, two-arm, randomised controlled trial. Patients aged ≥ 18 years who present with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (pPCI) will be enrolled after angiographic evidence of a high thrombus burden (TIMI thrombus grade ≥ 4) and meeting the inclusion criteria laid out in section 9.2 will be 1:1 randomised to receive either standalone PCI (Arm 1) or adjunct sustained mechanical thrombectomy + PCI (Arm 2).
- Phase 3: a large, late-stage study
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Primary PCI patient with ST elevation myocardial infarction
- Angiographic criteria:
- TIMI 0/1 flow at presentation
- Angiographic thrombus score ≥ 4
- Vessel diameter at site of occlusion ≥ 3.0mm (determined by coronary angiography)
You likely can't join if
- Female participant who is pregnant or lactating
- Unconscious at presentation
- Late STEMI presentation (symptoms onset to wire time \> 12 h)
- Clinically/haemodynamically unstable patients
- Known diagnosis of severe renal disease (CKD stage 4-5)
- Suspected spontaneous coronary artery dissection
See the full eligibility criteria
- Primary PCI patient with ST elevation myocardial infarction
- Angiographic criteria:
- TIMI 0/1 flow at presentation
- Angiographic thrombus score ≥ 4
- Vessel diameter at site of occlusion ≥ 3.0mm (determined by coronary angiography)
- Female participant who is pregnant or lactating
- Unconscious at presentation
- Late STEMI presentation (symptoms onset to wire time \> 12 h)
- Clinically/haemodynamically unstable patients
- Known diagnosis of severe renal disease (CKD stage 4-5)
- Suspected spontaneous coronary artery dissection
- Previous CABG
- Previous history on STEMI in the same culprit territory
- Known moderate-severe anaemia (Hb \< 9)
The study team makes the final eligibility decision.
Where it's taking place
- Oxford, Oxfordshire, United Kingdom
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Oxford, Oxfordshire, United Kingdom. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.