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New treatment option for Female Infertility Due to Diminished Ovarian Reserve
Official title Alpha-Lipoic Acid Supplementation and IVF Outcomes in Women of Advanced Maternal Age
ClinicalTrials.gov ID: NCT07685431
What this study is testing
- What it's testing
- Female fertility declines with advancing age, largely because of deteriorating oocyte quality driven by mitochondrial dysfunction and oxidative stress within the ovarian microenvironment. Alpha-lipoic acid (ALA) is a potent antioxidant that crosses cell and mitochondrial membranes, regenerates other antioxidants (vitamin C, vitamin E, glutathione, coenzyme Q10), and supports mitochondrial respiratory chain activity and ATP production.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 35 to 45, women only
You may be able to join if
- Age 35-45 years
- BMI 18-35 kg/m²
- Planning to undergo IVF treatment using own oocytes
You likely can't join if
- Primary ovarian insufficiency
- Azoospermia or severe male-factor infertility in the partner
- Congenital uterine anomaly
- Severe intrauterine adhesion
- Known chromosomal anomaly in either partner
- Malignancy
See the full eligibility criteria
- Age 35-45 years
- BMI 18-35 kg/m²
- Planning to undergo IVF treatment using own oocytes
- Primary ovarian insufficiency
- Azoospermia or severe male-factor infertility in the partner
- Congenital uterine anomaly
- Severe intrauterine adhesion
- Known chromosomal anomaly in either partner
- Malignancy
- Recipient of donor oocytes
- Known hypersensitivity/allergy to alpha-lipoic acid
The study team makes the final eligibility decision.
Where it's taking place
- Kaohsiung City, Taiwan
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling female, 35 years to 45 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Kaohsiung City, Taiwan. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.