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New treatment option for Kidney Disease, End-Stage
Official title Comparison of the Effects of General Anesthesia and Combined Spinal-Epidural Anesthesia on Ferroptosis, Humanin and MOTS-c Levels in Renal Transplantation
ClinicalTrials.gov ID: NCT07678073
What this study is testing
What is Sevoflurane General Anesthesia?
Sevoflurane General Anesthesia is an investigational medicine, given as an injection under the skin, being studied as a potential treatment for kidney disease, end-stage.
Also referred to as Sevoflurane anesthesia.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Renal transplantation is the most effective renal replacement therapy for patients with end-stage renal disease. Ischemia-reperfusion injury may adversely affect graft function and long-term outcomes.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 70
You may be able to join if
- Patients aged 18-70 years with American Society of Anesthesiologists (ASA) physical status I-III.
- Patients scheduled for elective living-donor allogeneic kidney transplantation.
- Patients receiving sevoflurane-based general anesthesia as the anesthetic technique.
- Patients receiving combined spinal-epidural anesthesia as the anesthetic technique.
You likely can't join if
- Patients younger than 18 years or older than 70 years.
- Patients undergoing deceased-donor kidney transplantation.
- Patients receiving total intravenous anesthesia (TIVA).
- Patients who decline to participate in the study or are unable to provide informed consent.
- Patients with American Society of Anesthesiologists (ASA) physical status IV or V.
- Patients with a history of previous organ transplantation.
See the full eligibility criteria
- Patients aged 18-70 years with American Society of Anesthesiologists (ASA) physical status I-III.
- Patients scheduled for elective living-donor allogeneic kidney transplantation.
- Patients receiving sevoflurane-based general anesthesia as the anesthetic technique.
- Patients receiving combined spinal-epidural anesthesia as the anesthetic technique.
- Patients younger than 18 years or older than 70 years.
- Patients undergoing deceased-donor kidney transplantation.
- Patients receiving total intravenous anesthesia (TIVA).
- Patients who decline to participate in the study or are unable to provide informed consent.
- Patients with American Society of Anesthesiologists (ASA) physical status IV or V.
- Patients with a history of previous organ transplantation.
- Patients with known or suspected mitochondrial disorders.
- Patients with a history of chronic corticosteroid use.
- Patients requiring red blood cell transfusion intraoperatively or within the first 24 postoperative hours.
- Patients with a primary warm ischemia time \>5 minutes, secondary warm ischemia time \>30 minutes, or cold ischemia time \>60 minutes.
The study team makes the final eligibility decision.
Where it's taking place
- Gaziantep, State/Province, Turkey (Türkiye)
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 70 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Gaziantep, State/Province, Turkey (Türkiye). Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.