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New treatment option for Epiphora
Official title Atropine Eye Drops for Watery Eyes (Excessive Tearing)
ClinicalTrials.gov ID: NCT07676981
What this study is testing
What is Atropine ophthalmic solution?
Atropine ophthalmic solution is an investigational medicine, being studied as a potential treatment for epiphora.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The goal of this clinical trial is to learn if low-dose atropine eye drops work to reduce excessive watery eyes (epiphora) in adults. It will also learn about the safety of the eye drops.
- Phase 2: a mid-size study of how well it works
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- You may be able to join if you:
- Are 18 years or older
- Have vision of 20/200 or better in at least one eye
- Have watery eyes (epiphora) bad enough to need wiping or dabbing at least twice a day
- Have watering caused by a functional/idiopathic, gustatory ("crocodile tears"), environmentally triggered (reflex), or obstructive cause - in one or...
See the full eligibility criteria
- You may be able to join if you:
- Are 18 years or older
- Have vision of 20/200 or better in at least one eye
- Have watery eyes (epiphora) bad enough to need wiping or dabbing at least twice a day
- Have watering caused by a functional/idiopathic, gustatory ("crocodile tears"), environmentally triggered (reflex), or obstructive cause - in one or both eyes
- Have a healthy eye surface, with no significant dry eye, active eye infection, or active eye inflammation
- Have adequate eyelid position and tone, where surgery is not the main treatment needed and reducing tear production is likely to help
- Are willing and able to put drops in your eye(s) once each night for 7 days and attend the study visits
- Can understand and follow the study procedures and communicate with study staff (an interpreter is allowed) You will not be able to join if you:
- Have significant dry eye disease
- Have had an active eye infection within the past 30 days
- Have an active tear-sac infection, or a blocked tear duct that needs urgent surgery (a blocked tear duct that does not need surgery is allowed)
- Currently use eye drops that affect tear production or eye-surface testing, unless you are willing to stop them for the study
- Are allergic to, or should not take, atropine, similar (anticholinergic) medicines, or any ingredient in the study drops
- Have narrow-angle or angle-closure glaucoma, where dilating the pupil would not be safe for you
- Are pregnant or breastfeeding
- Are taking part in another treatment study, or took part in one within 30 days before screening
- Have any condition that, in the doctor's judgment, would make it unsafe for you to join or hard to follow the study
The study team makes the final eligibility decision.
Where it's taking place
- Houston, Texas, United States
- Mesquite, Texas, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Houston, Texas, United States; Mesquite, Texas, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.