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New treatment option for Parkinson Disease
Official title Cross-System Effects of Acute Intermittent Hypercapnia-Based Interventions in PD
ClinicalTrials.gov ID: NCT07674264
What this study is testing
- What it's testing
- Parkinsonism impairs upper airway and axial motor control, leading to disordered breathing, reduced speech volume, and ineffective cough. Symptoms are poorly addressed by current therapies.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 40 to 75
You may be able to join if
- adults 40 to 75 years of age (the latter to reduce the likelihood of cardiovascular disease)
- diagnosis of idiopathic Parkinsonism with Hoehn and Yahr stages 2-4
- medically stable with physician clearance
- ability to ambulate at least 10 feet with/without assistance
- ability to follow directions
You likely can't join if
- additional neurologic conditions
- severe illness or infection, including respiratory/cardiovascular/lung disease, or uncontrolled hypertension
- inspiratory stridor
- pregnancy due to unknown tAIH effects on a fetus, although females of childbearing age will not be excluded\
- cigarette smoking or vaping within 5 years
- history of head/neck/lung cancer with the exception of basal cell carcinoma
See the full eligibility criteria
- adults 40 to 75 years of age (the latter to reduce the likelihood of cardiovascular disease)
- diagnosis of idiopathic Parkinsonism with Hoehn and Yahr stages 2-4
- medically stable with physician clearance
- ability to ambulate at least 10 feet with/without assistance
- ability to follow directions
- willing to abstain from blood donation for the duration of the study
- additional neurologic conditions
- severe illness or infection, including respiratory/cardiovascular/lung disease, or uncontrolled hypertension
- inspiratory stridor
- pregnancy due to unknown tAIH effects on a fetus, although females of childbearing age will not be excluded\
- cigarette smoking or vaping within 5 years
- history of head/neck/lung cancer with the exception of basal cell carcinoma
- is currently participating in another research study that could influence the results from this study
- has deep brain stimulation electrodes implanted or has a history of deep brain stimulation
- faints or becomes lightheaded at the sight of blood
- If a female of childbearing potential indicates there is a chance she could be pregnant, she will be provided a pregnancy test and allowed to continue in the study if negative. This is because the fetal risks associated...
The study team makes the final eligibility decision.
Where it's taking place
- Gainesville, Florida, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 40 years to 75 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Gainesville, Florida, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.