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New treatment option for Periodontal Disease
Official title Omega-3 Plus Low-Dose Aspirin in Smokers With Stage III Periodontitis
ClinicalTrials.gov ID: NCT07673185
What this study is testing
What is Omega-3 Fatty Acids (EPA plus DHA) plus low dose aspirin?
Omega-3 Fatty Acids (EPA plus DHA) plus low dose aspirin is an investigational medicine, given as a pill taken by mouth, being studied as a potential treatment for periodontal disease.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This randomized double-blind placebo-controlled clinical trial aims to evaluate the clinical and biochemical effects of omega-3 fatty acids combined with low-dose aspirin as an adjunct to scaling and root planing (SRP) in smoker patients with Stage III periodontitis. The study compares test and control groups regarding periodontal clinical parameters and gingival crevicular fluid interleukin-1 beta (IL-1β) levels Or other inflammatory markers that will be determined later at baseline, 3 months, and 6 months following treatment
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance. You may not know which one you got.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 30 to 50
You may be able to join if
- \- Male or female smokers aged 30 to 50 years.
- Diagnosed with Stage III periodontitis according to the 2017 World Workshop classification.
- Probing pocket depth (PPD) ≥ 5 mm.
- Clinical attachment loss (CAL) ≥ 5 mm.
- Presence of at least 20 natural teeth.
You likely can't join if
- \- Systemic diseases affecting periodontal health.
- Pregnancy or lactation.
- Periodontal treatment within the previous 6 months.
- Use of antibiotics or anti-inflammatory drugs within the previous 6 months.
- Allergy or hypersensitivity to omega-3 fatty acids or aspirin.
- Long-term anticoagulant therapy.
See the full eligibility criteria
- \- Male or female smokers aged 30 to 50 years.
- Diagnosed with Stage III periodontitis according to the 2017 World Workshop classification.
- Probing pocket depth (PPD) ≥ 5 mm.
- Clinical attachment loss (CAL) ≥ 5 mm.
- Presence of at least 20 natural teeth.
- Willing and able to provide written informed consent.
- \- Systemic diseases affecting periodontal health.
- Pregnancy or lactation.
- Periodontal treatment within the previous 6 months.
- Use of antibiotics or anti-inflammatory drugs within the previous 6 months.
- Allergy or hypersensitivity to omega-3 fatty acids or aspirin.
- Long-term anticoagulant therapy.
- History of gastric ulcer or bleeding disorders.
- Participation in another clinical trial within the previous 3 month
The study team makes the final eligibility decision.
Where it's taking place
- Cairo, Egypt
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 30 years to 50 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Cairo, Egypt. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.