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Official title Combined Regulatory Effects of 40 Hz eTNS and Multisensory Stimulation on Brain Networks
ClinicalTrials.gov ID: NCT07668167
What this study is testing
- What it's testing
- The purpose of this study is to investigate the independent and interactive effects of 40Hz auditory, visual, and external trigeminal nerve stimulation (eTNS) on brain state dynamics and functional connectivity. While 40Hz visual and auditory sensory stimulation have been explored for potential cognitive and therapeutic benefits, the underlying mechanisms on large-scale brain networks and the potential effects of combining multiple modalities remain unclear.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older. Healthy volunteers may be eligible.
You may be able to join if
- Healthy adults aged ≥18 years old.
- Normal or corrected-to-normal vision and hearing (essential for 40Hz visual and auditory stimulation).
- Right-handedness.
- Willing to participate in the study and capable of providing written informed consent.
You likely can't join if
- Personal or family history of epilepsy or seizures (crucial safety criteria for 40Hz flicker and electrical stimulation).
- History of any neurological or psychiatric disorders.
- Presence of metallic implants in the head, cardiac pacemakers, or other implanted electronic medical devices.
- Skin lesions, infections, or hypersensitivity at the eTNS stimulation site (maxillary branch of the trigeminal nerve).
- Current use of psychoactive medications or substances that may significantly alter EEG signals or brain state dynamics.
- Pregnant or lactating individuals.
See the full eligibility criteria
- Healthy adults aged ≥18 years old.
- Normal or corrected-to-normal vision and hearing (essential for 40Hz visual and auditory stimulation).
- Right-handedness.
- Willing to participate in the study and capable of providing written informed consent.
- Personal or family history of epilepsy or seizures (crucial safety criteria for 40Hz flicker and electrical stimulation).
- History of any neurological or psychiatric disorders.
- Presence of metallic implants in the head, cardiac pacemakers, or other implanted electronic medical devices.
- Skin lesions, infections, or hypersensitivity at the eTNS stimulation site (maxillary branch of the trigeminal nerve).
- Current use of psychoactive medications or substances that may significantly alter EEG signals or brain state dynamics.
- Pregnant or lactating individuals.
- Poor sleep quality or irregular sleep-wake cycles prior to the experiment.
The study team makes the final eligibility decision.
Where it's taking place
- Xi'an, Shaanxi, China
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Xi'an, Shaanxi, China. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.