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Compares treatment options for Cough
Official title Oliceridine vs Sufentanil for Cough During Anesthesia Induction
ClinicalTrials.gov ID: NCT07660380
What this study is testing
What is Oliceridine?
Oliceridine is an investigational medicine, given as an infusion into a vein, being studied as a potential treatment for cough.
Also referred to as TRV130, Oliceridine Fumarate.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Sufentanil is the most widely used opioid analgesic for general anaesthesia induction; however, rapid intravenous bolus injection frequently triggers sufentanil-induced cough (SIC). In high-risk patients, SIC can cause abrupt elevation of intracranial and intraocular pressure and severe haemodynamic instability, posing a meaningful safety risk during the induction period.
- Phase 4: studies an already-approved treatment
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 99
You may be able to join if
- Aged 18 to 99 years.
- American Society of Anesthesiologists (ASA) physical status classification I, II, or III.
- Body mass index (BMI) between 18.5 and 28.0 kg/m².
- Scheduled for elective surgery under general anaesthesia.
- Able to understand the study procedures and provide written informed consent.
You likely can't join if
- Preoperative upper respiratory tract infection symptoms (e.g., cough, expectoration, or fever) or a history of bronchial asthma or other conditions...
- Severe cardiovascular disease (e.g., uncontrolled hypertension, recent myocardial infarction, or serious arrhythmia) or hepatic or renal dysfunction.
- Long-term opioid use, defined as continuous opioid use for more than 2 weeks within the 3 months prior to surgery.
- Known hypersensitivity to any study drug or anaesthetic agent used in this protocol.
- Anticipated difficult airway requiring awake intubation.
- Pregnancy or breastfeeding.
The study team makes the final eligibility decision.
Where it's taking place
- Tianmen, Hubei, China
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 99 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Tianmen, Hubei, China. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.