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Compares treatment options for Peripheral Nerve Injury
Official title A Prospective, Randomized, Assessor-Blinded, Multicenter Study Comparing Avance Nerve Graft and Autograft for Functional Recovery Following Mixed and Motor Peripheral Nerve Reconstruction
ClinicalTrials.gov ID: NCT07657182
What this study is testing
What is Avance Nerve Graft?
Avance Nerve Graft is an investigational medicine, being studied as a potential treatment for peripheral nerve injury.
Also referred to as Acellular nerve allograft-arwx.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This is a multicenter, 1:1 randomized, prospective, comparative study in participants requiring reconstruction of a mixed or motor nerve in the upper extremity. This study will consist of a screening visit, an operative visit, and 9 post-operative follow-up visits at Week 4, and Months 3, 6, 9, 12, 15, 18, 21, and 24.
- Phase 4: studies an already-approved treatment
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Study Participant Criteria
- Be ≥ 18 years of age at the time of consent;
- Willing and able to comply with all aspects of the treatment and evaluation schedule over a 24-month duration;
- Provide documented Institutional Review Board (IRB)/Independent Ethics Committee (IEC)-approved informed consent prior to initiation of any study...
- Primary or secondary nerve injury repair with sural nerve autograft or Avance Nerve Graft for fully transected reconstruction of the following upper...
You likely can't join if
- Study Participant Criteria
- Currently enrolled in another clinical study that may interfere with treatment, assessment of recovery, or participation in this study;
- Deformities or injuries of the limb, hand, or digits that affect both the primary and secondary assessments for eligible nerve repair(s);
- History of neuropathy of any etiology, diabetic neuropathy or any other known neuropathy including compressive/traumatic neuropathies affecting the...
- History of progressive neurodegenerative or autoimmune disorder affecting peripheral nerve or motor function (e.g., amyotrophic lateral sclerosis...
- History of chronic ischemic condition of the upper extremity;
See the full eligibility criteria
- Study Participant Criteria
- Be ≥ 18 years of age at the time of consent;
- Willing and able to comply with all aspects of the treatment and evaluation schedule over a 24-month duration;
- Provide documented Institutional Review Board (IRB)/Independent Ethics Committee (IEC)-approved informed consent prior to initiation of any study procedures; Injury/Repair Criteria for Each Nerve
- Primary or secondary nerve injury repair with sural nerve autograft or Avance Nerve Graft for fully transected reconstruction of the following upper extremity mixed and/or motor nerve(s):
- Median nerve: proximal nerve stump within 20 cm from the center point of the thenar eminence and distal to the crease of the elbow;
- Anterior interosseous nerve;
- Median nerve recurrent motor branch;
- Radial nerve: proximal nerve stump within 20 cm of the center of the forearm (midpoint between the tip of the olecranon and the styloid process) and distal to the mid-humerus;
- Posterior interosseous nerve.
- Zone of injury of eligible nerve(s) resectable to healthy nerve both distally and proximally and within the anatomical regions of Inclusion Criterion #4;
- In study participants with multiple eligible nerve repairs, repair of all eligible nerves completed with the same study treatment, either Avance Nerve Graft or sural nerve autograft;
- Measured nerve gap(s) following resection \> 25 mm;
- Nerve(s) repaired ≤ 120 days post injury;
- Undergo coaptation on both the proximal and distal portion of the nerve gap(s) per the USPI for Avance Nerve Graft and per standard of care for sural nerve autograft; and
- Either treatment method, Avance Nerve Graft or sural nerve autograft, is a viable option for all eligible nerve repair(s) (i.e., volume of injured nerve(s) does not exceed availability of sural nerve autograft for...
- Study Participant Criteria
- Currently enrolled in another clinical study that may interfere with treatment, assessment of recovery, or participation in this study;
- Deformities or injuries of the limb, hand, or digits that affect both the primary and secondary assessments for eligible nerve repair(s);
- History of neuropathy of any etiology, diabetic neuropathy or any other known neuropathy including compressive/traumatic neuropathies affecting the target limb;
- History of progressive neurodegenerative or autoimmune disorder affecting peripheral nerve or motor function (e.g., amyotrophic lateral sclerosis, multiple sclerosis, Parkinson's disease);
- History of chronic ischemic condition of the upper extremity;
- Expected use of medication during the study that is known to impact nerve regeneration or to cause peripheral neuropathy;
- Undergoing or expected to undergo treatment with chemotherapy, radiation therapy, or other known treatment which affects the growth of neural and/or vascular systems;
- Participant is unlikely to comply with all study requirements and standard medical care procedures for the duration of the study schedule; Injury/Repair Criteria for Each Nerve
- Median nerve repairs where the ulnar nerve has been transected due to injury or repair;
- Repair(s) of a sensory-only proximal nerve stump;
- Incomplete nerve transections;
- Multilevel nerve injury pattern requiring two or more isolated reconstructions along the nerve pathway (for example, reconstruction of median nerve in forearm and recurrent motor branch resulting in repair pattern of...
- Inadequate soft tissue coverage or extensive soft tissue injury which will impair recovery assessment;
- Nerve avulsion injuries and nerve traction injuries resulting in rupture of the nerve;
- Replantation/amputation of the limb, hand, or digits involved in both the primary and secondary assessments for eligible nerve repair(s);
- Nerve repairs utilizing either end-to-side or side-to-side coaptation techniques;
- Nerve transfer, tendon transfer, or other concomitant treatment at the time of nerve repair that affects assessment of function of the innervated muscle organ;
- Use of coaptation devices that include metallic components or activated polymers and coaptations completed with fibrin glue only; and
- Injuries with vascular damage resulting in inadequate perfusion despite repair (i.e., both radial and ulnar arteries injured [one injured artery is allowed]).
The study team makes the final eligibility decision.
Where it's taking place
- Indianapolis, Indiana, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Indianapolis, Indiana, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.