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New treatment option for Dry Eye Disease (DED)
Official title Dose-Finding Study of HUC1-394 in Participants With Dry Eye Disease
ClinicalTrials.gov ID: NCT07656688
What this study is testing
What is HUC1-394?
HUC1-394 is an investigational medicine, being studied as a potential treatment for dry eye disease (ded).
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Clinical trial aims to determine the optimal dosing regimen by evaluating the efficacy and safety of HUC1-394 across different dosing frequencies in patients with moderate to severe dry eye disease.
- Phase 2: a mid-size study of how well it works
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 19 and older
You may be able to join if
- Adults aged ≥ 19 years at the time of screening
- Trial participants who have experienced at least one of the following dry eye disease symptoms for at least 3 months prior to the time of screening
- Trial participants who meet all of the following criteria in at least one eye (left or right) at the time of screening and randomization: TCSS (NEI...
- OSDI score ≥ 23 at the time of screening
- Trial participants who have provided voluntary written informed consent after receiving a full explanation and understanding of the clinical trial
You likely can't join if
- Trial participants with clinically significant ophthalmic diseases that may confound the interpretation of clinical trial results
- Trial participants with blepharospasm, entropion, ectropion, or abnormalities of the eyelashes
- Trial participants with any active ophthalmic disease that may affect the ocular surface, such as active allergy, anterior uveitis, and...
- Trial participants with a history of corneal transplantation or neurotrophic keratitis
- Trial participants with autoimmune diseases or immunodeficiency disorders
- Pregnant or lactating women, or women of childbearing potential and men of reproductive potential who plan to conceive during the clinical trial or...
See the full eligibility criteria
- Adults aged ≥ 19 years at the time of screening
- Trial participants who have experienced at least one of the following dry eye disease symptoms for at least 3 months prior to the time of screening
- Trial participants who meet all of the following criteria in at least one eye (left or right) at the time of screening and randomization: TCSS (NEI grading) ≥ 4 / Non-anesthetic Schirmer test result \> 0 mm and ≤ 10...
- OSDI score ≥ 23 at the time of screening
- Trial participants who have provided voluntary written informed consent after receiving a full explanation and understanding of the clinical trial
- Trial participants with clinically significant ophthalmic diseases that may confound the interpretation of clinical trial results
- Trial participants with blepharospasm, entropion, ectropion, or abnormalities of the eyelashes
- Trial participants with any active ophthalmic disease that may affect the ocular surface, such as active allergy, anterior uveitis, and Stevens-Johnson syndrome
- Trial participants with a history of corneal transplantation or neurotrophic keratitis
- Trial participants with autoimmune diseases or immunodeficiency disorders
- Pregnant or lactating women, or women of childbearing potential and men of reproductive potential who plan to conceive during the clinical trial or are unwilling to use an appropriate method of contraception
- Trial participants who have participated in another clinical trial and received an investigational product or used an investigational medical device within 30 days prior to the time of screening
- Trial participants who are deemed ineligible for participation by the investigator for any other reason in the clinical trial
The study team makes the final eligibility decision.
Where it's taking place
- Seoul, South Korea
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 19 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Seoul, South Korea. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.