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Tests treatment safety and results for ESRD (End-Stage Renal Disease)
Official title Efficacy of pHA130 Hemoadsorption on Protein-Bound Uremic Toxins and Quality of Life in Kidney Failure
ClinicalTrials.gov ID: NCT07656168
What this study is testing
- What it's testing
- Patients on maintenance hemodialysis (MHD) face a high risk of cardiovascular mortality and reduced quality of life. Conventional high-flux hemodialysis (HD) is the standard of care but has limited efficacy in clearing middle-molecular and protein-bound uremic toxins (PBUTs).
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Age \> 18 years.
- On maintenance hemodialysis for \> 3 months.
- Receiving hemodialysis 3 times per week, 4 hours per session.
- Standard Kt/V ≥ 1.2.
- Voluntarily participates and provides written informed consent.
You likely can't join if
- Known allergy to the dialyzer or hemoperfusion device.
- Platelet count \< 60×10⁹/L.
- Serum albumin \< 30 g/L.
- 24-hour urine output \> 200 ml.
- Inability to achieve a blood flow rate ≥ 200 ml/min.
- Coagulation disorders, severe bleeding tendency, or active bleeding.
See the full eligibility criteria
- Age \> 18 years.
- On maintenance hemodialysis for \> 3 months.
- Receiving hemodialysis 3 times per week, 4 hours per session.
- Standard Kt/V ≥ 1.2.
- Voluntarily participates and provides written informed consent.
- Known allergy to the dialyzer or hemoperfusion device.
- Platelet count \< 60×10⁹/L.
- Serum albumin \< 30 g/L.
- 24-hour urine output \> 200 ml.
- Inability to achieve a blood flow rate ≥ 200 ml/min.
- Coagulation disorders, severe bleeding tendency, or active bleeding.
- Pre-dialysis systolic blood pressure \< 90 mmHg or diastolic blood pressure \< 60 mmHg.
- Active malignancy.
- Active infection, or severe, critical illness of cardiac, pulmonary, hepatic, or nervous systems.
- Planned living-donor kidney transplant within the next 6 months.
- Current participation in another treatment clinical study, or participation within the past 3 months in an treatment study that may interfere with the present study (e.g., fecal microbiota transplantation); or use of...
- History of unstable angina, myocardial infarction, malignant arrhythmia, cardiac or peripheral vascular surgery, or cerebrovascular accident within the past 8 weeks.
The study team makes the final eligibility decision.
Where it's taking place
- Beijing, China
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Beijing, China. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.