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New treatment option for Mild Cognitive Impairment (MCI)
Official title Using Light Therapy for Mild Cognitive Impairment
ClinicalTrials.gov ID: NCT07651787
What this study is testing
- What it's testing
- The goal of this clinical trial is to test whether transcranial photobiomodulation (tPBM), a non-invasive brain stimulation technique using near-infrared light, can improve brain blood flow regulation (neurovascular coupling) and cognitive function in people with mild cognitive impairment (MCI). The main questions it aims to answer are: Does tPBM enhance cognitive function and cerebral hemodynamic responses during memory and finger tapping tasks?
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 55 to 95
You may be able to join if
- Age: 55-95 years of age
- Clinical Dementia Rating (CDR) equal to 0.5 and/or Montreal Cognitive Assessment (MoCA) \<26 and ≥19
- Adequate hearing and visual acuity to participate in the examinations
- English speaker
- Presence of cerebrovascular pathology confirmed by structural brain imaging method
You likely can't join if
- Active CNS disease including multiple sclerosis, uncontrolled seizures, active brain cancer
- Cerebrovascular accident other than TIA within 60 days prior to Visit 0
- Diagnosis of amyloid angiopathy
- Major psychiatric disease, including major depression not controlled on medications, alcohol or drug abuse
- Neurodegenerative diseases, e.g: Parkinson's, any kind of dementia
- Patients currently using commercial brain stimulation / neuromodulation device as part of a research study
See the full eligibility criteria
- Age: 55-95 years of age
- Clinical Dementia Rating (CDR) equal to 0.5 and/or Montreal Cognitive Assessment (MoCA) \<26 and ≥19
- Adequate hearing and visual acuity to participate in the examinations
- English speaker
- Presence of cerebrovascular pathology confirmed by structural brain imaging method
- Active CNS disease including multiple sclerosis, uncontrolled seizures, active brain cancer
- Cerebrovascular accident other than TIA within 60 days prior to Visit 0
- Diagnosis of amyloid angiopathy
- Major psychiatric disease, including major depression not controlled on medications, alcohol or drug abuse
- Neurodegenerative diseases, e.g: Parkinson's, any kind of dementia
- Patients currently using commercial brain stimulation / neuromodulation device as part of a research study
- Patients currently take dietary supplements with an expected cerebrovascular benefit such as NAD- or NR-supplementum, L-citrullin, urolithin
- Unstable medical condition, including uncontrolled diabetes, chronic heart issues, heart failure, chronic obstructive pulmonary disease, hypertension uncontrolled by medication (\>160/100 mmHg)
- Any other medical condition or medication which, in the opinion of investigator, would render the patient too unstable to complete the study protocol
- Severe sensory deficits interfering with the testing
The study team makes the final eligibility decision.
Where it's taking place
- Oklahoma City, Oklahoma, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 55 years to 95 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Oklahoma City, Oklahoma, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.