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Official title Nicotinamide Riboside, Vit B3 Analogue, and Brain Energy Metabolism
ClinicalTrials.gov ID: NCT07649161
What this study is testing
- What it's testing
- The goal of this clinical trial is to learn how nicotinamide riboside (NR), a form of vitamin B3, affects brain energy metabolism in healthy adults. Researchers want to find out if taking NR by mouth for 2 weeks can raise the balance of two related brain chemicals called NAD+ and NADH, which play a key role in how cells make and use energy.
- Time commitment: about 2 weeks
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 65. Healthy volunteers may be eligible.
You may be able to join if
- Adults (between 18 and 65 years old)
- Without a current psychiatric diagnosis assessed by a structured psychiatric interview at the screening/consent visit
- Without a history of a psychotic disorder and/or mood disorder among parents, siblings, or children
You likely can't join if
- Any current significant medical or neurological illness.
- Diagnosis of diabetes mellitus (DM), uncontrolled hypertension (HTN), severe hypotension, coronary artery disease (CAD), metabolic syndrome...
- Currently taking any other medications, including over-the-counter supplements except oral contraceptives for women and Tylenol as needed for pain or...
- Currently pregnant or breastfeeding. Females of child-bearing age must be using an effective contraceptive method.
- History of substance abuse or dependence.
- Contraindication to MR scan (claustrophobia, cardiac pacemakers, metal clips and stents on blood vessels, artificial heart valves, artificial arms...
See the full eligibility criteria
- Adults (between 18 and 65 years old)
- Without a current psychiatric diagnosis assessed by a structured psychiatric interview at the screening/consent visit
- Without a history of a psychotic disorder and/or mood disorder among parents, siblings, or children
- Any current significant medical or neurological illness.
- Diagnosis of diabetes mellitus (DM), uncontrolled hypertension (HTN), severe hypotension, coronary artery disease (CAD), metabolic syndrome, glaucoma, liver impairment, decreased renal function, respiratory disorders...
- Currently taking any other medications, including over-the-counter supplements except oral contraceptives for women and Tylenol as needed for pain or headache.
- Currently pregnant or breastfeeding. Females of child-bearing age must be using an effective contraceptive method.
- History of substance abuse or dependence.
- Contraindication to MR scan (claustrophobia, cardiac pacemakers, metal clips and stents on blood vessels, artificial heart valves, artificial arms, hands, legs, etc., brain stimulator devices, implanted drug pumps, ear...
- Medical condition that would prevent blood draws, including current anti-coagulant or anti-aggregant therapy, tendency for abnormal scarring (e.g., keloids).
- Difficulty in swallowing capsules.
The study team makes the final eligibility decision.
Where it's taking place
- Boston, Massachusetts, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The study runs about 2 weeks per participant, based on its public description. The team confirms the exact schedule and number of visits before you enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 65 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Boston, Massachusetts, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.