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New treatment option for Stroke
Official title Telerehabilitation and Biomarkers of Recovery After Stroke in Brazil
ClinicalTrials.gov ID: NCT07646522
What this study is testing
- What it's testing
- The purpose of this research study is to provide preliminary evidence of whether telerehabilitation targeting arm movement, when added to usual care, improves arm function and reduces global disability after stroke, compared to usual care alone in Brazil. Evaluate the safety and feasibility of telerehabilitation in the Brazilian context.
- Phase 2: a mid-size study of how well it works
- Time commitment: about 6 weeks
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 80
You may be able to join if
- Age 18-80 years at the time of randomization.
- The index stroke was radiologically verified, due to ischemia, and had time of onset 120±30 days prior to randomization.
- The stroke caused upper extremity deficits as defined by Action Research.
- Arm Test score 18-44 (out of 57) at Baseline Visit.
- Box \& Block Test score with affected arm is ≥1 block in 60 seconds at Baseline Visit.
You likely can't join if
- A major, active, coexistent neurological, psychiatric, or medical disease that reduces the likelihood that a subject will be able to comply with all...
- Unable or unwilling to perform study procedures/therapy, or expectation of noncompliance with study procedures/therapy, or expectation that subject...
- A diagnosis (apart from the index stroke) that substantially affects paretic arm function.
- Severe depression, defined as Geriatric Depression Scale Score \>10/15 at Baseline Visit.
- Significant cognitive impairment, defined as Montreal Cognitive Assessment [a lower score can be permitted at the discretion of the PI].
- Deficits in communication that interfere with reasonable study participation.
See the full eligibility criteria
- Age 18-80 years at the time of randomization.
- The index stroke was radiologically verified, due to ischemia, and had time of onset 120±30 days prior to randomization.
- The stroke caused upper extremity deficits as defined by Action Research.
- Arm Test score 18-44 (out of 57) at Baseline Visit.
- Box \& Block Test score with affected arm is ≥1 block in 60 seconds at Baseline Visit.
- Able to successfully perform all 3 rehabilitation exercise test examples (simple commands) at Baseline Visit.
- Informed consent and behavioral contract signed by the subject (i.e., no surrogate consent).
- A major, active, coexistent neurological, psychiatric, or medical disease that reduces the likelihood that a subject will be able to comply with all study procedures.
- Unable or unwilling to perform study procedures/therapy, or expectation of noncompliance with study procedures/therapy, or expectation that subject cannot participate in all study visits.
- A diagnosis (apart from the index stroke) that substantially affects paretic arm function.
- Severe depression, defined as Geriatric Depression Scale Score \>10/15 at Baseline Visit.
- Significant cognitive impairment, defined as Montreal Cognitive Assessment [a lower score can be permitted at the discretion of the PI].
- Deficits in communication that interfere with reasonable study participation.
- Severe UE spasticity, defined as presence of contracture or modified Ashworth Scale score=4 in either biceps or pectoralis.
- Modified Rankin Scale score \>2 prior to the index stroke.
- A new symptomatic stroke has occurred since the index stroke, or a separate stroke occurred within 30 days prior to the index stroke.
- Lacking visual acuity, with or without corrective lens, of 20/50 or better in at least one eye.
- Life expectancy \< 9 months
- Pregnancy; women of child-bearing potential must have a negative pregnancy test.
- Botulinum toxin to the paretic arm: received in the prior 3 months or expected by the 1-Month Visit.
- Concurrent enrollment in another therapy-based investigational study where the duration of the investigational therapy's activity is likely to occur during the subject's participation in the study.
- Subject lacks sufficient Portuguese to comply with study procedures and TR instructions.
- Contraindication to MRI.
- Contraindication to TMS.
- Box and Block Test score of ≥30 blocks with the unaffected arm within 60 seconds at Baseline Visit;
- Spatial neglect interfering with reasonable participation in the study;
- On isolation precautions, e.g., due to active COVID-19.
- Expectation that participant will not have a single domicile address during the 6 weeks of therapy.
- Distance from the participant's home to the study site greater than 120 km [this can be waived at the discretion of the PI]. 22\. Availability of a 2 m² space for a table and chair setup.
The study team makes the final eligibility decision.
Where it's taking place
- Ribeirão Preto, São Paulo, Brazil
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The study runs about 6 weeks per participant, based on its public description. The team confirms the exact schedule and number of visits before you enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 80 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Ribeirão Preto, São Paulo, Brazil. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.