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New treatment option for Cancer (Advanced Stage)
Official title SBRT-LATTICE-PATHY
ClinicalTrials.gov ID: NCT07645261
What this study is testing
- What it's testing
- To assess the importance of using SBRT-LATTICE-PATHY for the radiotherapy treatment of large tumors that would be considered intractable by currently used standard techniques. In this present study, the investigators will have the possibility of combining SBRT and LATTICE techniques, incorporating the concept of hypoxic tissue irradiation, which are potential modulators of abscopal and bystander effects, performing partial punctual treatment in the vertex region, without the need for irradiation of the entire tissue volume, further improving safety in relation to possible toxicities.
- Phase 2: a mid-size study of how well it works
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- age =or\> 18 years;
- Eastern Cooperative Oncology Group (ECOG) performance status \< 2; benign and malignant tumors for which the use of radiotherapy is well established...
- tumors =or\> 340 cm³ or with a largest diameter =or\> 7 cm;
- no indication for any other type of treatment due to lack of proven clinical benefit (surgery, chemotherapy, standard radiotherapy, immunotherapy...
- Palliative Prognostic Index (PPI) =or\< 2;
You likely can't join if
- cases in which tumor volume and/or the patient's clinical condition make adequate immobilization/simulation impossible;
- previous local radiotherapy;
- pregnant patients;
- autoimmune diseases;
- genetic instability syndromes;
- ongoing systemic therapy;
See the full eligibility criteria
- age =or\> 18 years;
- Eastern Cooperative Oncology Group (ECOG) performance status \< 2; benign and malignant tumors for which the use of radiotherapy is well established in the literature;
- tumors =or\> 340 cm³ or with a largest diameter =or\> 7 cm;
- no indication for any other type of treatment due to lack of proven clinical benefit (surgery, chemotherapy, standard radiotherapy, immunotherapy, targeted therapy, etc.);
- Palliative Prognostic Index (PPI) =or\< 2;
- metastatic disease in the central nervous system (CNS), if present, controlled (up to 3 metastases, each up to 1 cm);
- up to 5 extracranial distant metastases (nodal or extranodal) =or\< 5 cm; signed Informed Consent Form (ICF).
- cases in which tumor volume and/or the patient's clinical condition make adequate immobilization/simulation impossible;
- previous local radiotherapy;
- pregnant patients;
- autoimmune diseases;
- genetic instability syndromes;
- ongoing systemic therapy;
- renal insufficiency that prevents the use of iodinated contrast.
The study team makes the final eligibility decision.
Where it's taking place
- São Paulo, São Paulo, Brazil
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include São Paulo, São Paulo, Brazil. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.