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Compares treatment options for Analgesia Assessment
Official title The Analgesic Efficacy of Dexmedetomidine Versus Fentanyl as an Adjuvant to Bupivacaine in Ultrasound Guided Peripheral Nerve Blocks as a Solo Anesthetic Technique in High Risk Patients Undergoing Unilateral Above Knee Amputation .
ClinicalTrials.gov ID: NCT07640516
What this study is testing
What is Dexmedetomidine?
Dexmedetomidine is an investigational medicine, being studied as a potential treatment for analgesia assessment.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The aim of this study is to compare the analgesic efficacy and safety of dexmedetomidine versus fentanyl as adjuvants to bupivacaine in ultrasound-guided combined supra-inguinal fascia iliaca and proximal sciatic nerve blocks used as a solo anesthetic technique in high-risk patients undergoing unilateral above knee amputation.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- \- Age ≥18 years
- Both sexes
- ASA III-IV
- Documented cardiac disease (e.g., EF \< 40%, NYHA II or higher)
- Documented pulmonary disease (e.g., COPD with FEV1 \< 60%)
You likely can't join if
- Neurological or intellectual disability
- Drug abuse
- Allergy to study drugs
- Pregnancy
- Contraindications to regional anesthesia (e.g., coagulopathy, local infection)
- Significant renal or hepatic impairment( plts \ 1.5)
See the full eligibility criteria
- \- Age ≥18 years
- Both sexes
- ASA III-IV
- Documented cardiac disease (e.g., EF \< 40%, NYHA II or higher)
- Documented pulmonary disease (e.g., COPD with FEV1 \< 60%)
- Scheduled for above-knee amputations
- Neurological or intellectual disability
- Drug abuse
- Allergy to study drugs
- Pregnancy
- Contraindications to regional anesthesia (e.g., coagulopathy, local infection)
- Significant renal or hepatic impairment( plts \ 1.5)
- Current anticoagulant therapy
- severe haemodynamically unstability at the time of block performance, defined as map \> 65 mmhg but achieved by high-dose vasopressors (e.g., norepinephrine ≥ 0.1 mcg/kg/min) after fluid ressuscitation .
The study team makes the final eligibility decision.
Where it's taking place
- Cairo, Egypt
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Cairo, Egypt. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.