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New treatment option for Dystonia Disorder
Official title Impact of rTMS on Abnormal Cortical fMRI in Patients With Dystonia
ClinicalTrials.gov ID: NCT07626216
What this study is testing
- What it's testing
- By tracking resting-state fMRI scans, we aim to discover how repetitive transcranial magnetic stimulation (rTMS) changes brain connectivity in individuals with dystonia.
- Phase 1: an early, usually small safety study
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 80
You may be able to join if
- Male or female
- 18 and 80 years of age.
- Patients who manifest dystonia - sustained involuntary movement of the head, neck, trunk or limbs.
- The dystonia may be spontaneous or genetic, specifically DYT1 or DYT6 and then only those patients who are demonstrating dystonia. The...
You likely can't join if
- Heredodegenrative dystonia of the type DYT8,9 or 10.
- Past history of head trauma, stroke, epilepsy, demyelinating disease
- Hypertension in excess of 160mmHg systolic and 90mmHg diastolic
- Congestive heart failure
- Diabetes
- Past psychiatric conditions: e.g., depression
See the full eligibility criteria
- Male or female
- 18 and 80 years of age.
- Patients who manifest dystonia - sustained involuntary movement of the head, neck, trunk or limbs.
- The dystonia may be spontaneous or genetic, specifically DYT1 or DYT6 and then only those patients who are demonstrating dystonia. The patient/subject will have a normal neurological exam except for dystonia.
- Heredodegenrative dystonia of the type DYT8,9 or 10.
- Past history of head trauma, stroke, epilepsy, demyelinating disease
- Hypertension in excess of 160mmHg systolic and 90mmHg diastolic
- Congestive heart failure
- Diabetes
- Past psychiatric conditions: e.g., depression
- Systemic metabolic disease: e.g., Wilson's disease, progressive neurodegenerative disease (like supranuclear palsy or corticobasal ganglionic degeneration)
- Magnetizable incorporated metal parts - like pacemakers
- History or diagnosis of Parkinson's disease
- Presence of myoclonus
- No previous surgery for dystonia
- Long term exposure to benzodiazepines, neuroleptics or anticonvulsants
- No botulinum toxin within 12 weeks of baseline assessment and fMRI.
- Moderate to severe cognitive impairment (judged by a minimental status of \<24.)
The study team makes the final eligibility decision.
Where it's taking place
- Manhasset, New York, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 80 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Manhasset, New York, United States. Enter your location above to see the nearest site and check your eligibility.
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BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.