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Official title Investigating the Effect of Caffeine and Alcohol on Pupil Dynamics
ClinicalTrials.gov ID: NCT07625358
What this study is testing
- What it's testing
- The goal of this study is to understand how caffeine and alcohol affect the ocular and physiological systems, especially how the pupil (the aperture in the colored part of the eye) responds to light. It will also test whether these changes can be used to detect recent caffeine or alcohol intake using a portable eye device.
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance. You may not know which one you got.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 30 to 50. Healthy volunteers may be eligible.
You may be able to join if
- Participants must meet the , as shown below, to participate in this study
- Age: 30 to 50 years of age
- Visual Acuity: Best Corrected Visual Acuity (BCVA) of 0.20 LogMAR or better in both eyes
- Ability to provide informed consent: Participants must be able to understand and sign the informed consent form
- Ability to consume both caffeine and alcohol: Participants must be willing and able to consume caffeine and alcohol as part of the study Participants...
You likely can't join if
- , as shown in the table below, will be excluded from participation. Exclusion Criteria
- Diagnosed ocular conditions: Participants with ocular or ocular movement diseases such as glaucoma, age-related macular degeneration, diabetic...
- Diagnosed and unresolved neurological conditions:Stroke, unresolved traumatic brain injury, space-occupying lesions in the brain, neuropathies...
- Diagnosed systemic conditions that may restrict the participant from drinking caffeine or alcohol: Hypertension, cardiovascular disease, liver...
- Medications: Participants taking any medications that may interact with caffeine or alcohol, affect alertness, or cause drowsiness
- Previous complex intraocular eye surgery: Participants who have undergone any eye surgery other than uncomplicated refractive surgery.
See the full eligibility criteria
- Participants must meet the , as shown below, to participate in this study
- Age: 30 to 50 years of age
- Visual Acuity: Best Corrected Visual Acuity (BCVA) of 0.20 LogMAR or better in both eyes
- Ability to provide informed consent: Participants must be able to understand and sign the informed consent form
- Ability to consume both caffeine and alcohol: Participants must be willing and able to consume caffeine and alcohol as part of the study Participants meeting any of the
- , as shown in the table below, will be excluded from participation. Exclusion Criteria
- Diagnosed ocular conditions: Participants with ocular or ocular movement diseases such as glaucoma, age-related macular degeneration, diabetic retinopathy, amblyopia, severe ptosis, or conditions relating to pupils...
- Diagnosed and unresolved neurological conditions:Stroke, unresolved traumatic brain injury, space-occupying lesions in the brain, neuropathies, demyelinating conditions, nerve palsies, etc.
- Diagnosed systemic conditions that may restrict the participant from drinking caffeine or alcohol: Hypertension, cardiovascular disease, liver disease, kidney disease, etc.
- Medications: Participants taking any medications that may interact with caffeine or alcohol, affect alertness, or cause drowsiness
- Previous complex intraocular eye surgery: Participants who have undergone any eye surgery other than uncomplicated refractive surgery.
- Pregnancy or breastfeeding: Pregnant or breastfeeding women will be excluded from the study, as caffeine and alcohol can affect the fetus or baby
- History of substance abuse: Participants with a history of substance abuse
- Allergies or sensitivities: Participants with allergies or sensitivities to caffeine or alcohol
- Shift work or having travelled across 2 time zones over the past 2 weeks: This is essential to avoid any impact of sleep deprivation on our outcome measures
- Non-consumers or light-consumers of caffeine and alcohol Participants who are light consumers of caffeine or alcohol will be excluded due to higher sensitivity to side effects. Caffeine: If less than 100 mg of caffeine...
The study team makes the final eligibility decision.
Where it's taking place
- Singapore, Singapore
Compensation & support
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 30 years to 50 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Singapore, Singapore. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.