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New treatment option for Lipoprotein(a)
Official title A Clinical Trial of MK-7262 and Enlicitide in Participants With High Lipoprotein(a) (MK-7262-004)
ClinicalTrials.gov ID: NCT07614984
What this study is testing
What is MK-7262?
MK-7262 is an investigational medicine, given as a pill taken by mouth, being studied as a potential treatment for lipoprotein(a).
Also referred to as HRS-5346.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Researchers designed a trial medicine called MK-7262 to lower levels of Lp(a) in the blood. Researchers want to learn about giving MK-7262 with another trial medicine called enlicitide (also known as MK-0616 or enlicitide decanoate).
- Phase 2: a mid-size study of how well it works
- You might receive a placebo (an inactive treatment) instead of the study drug.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- The main include but are not limited to the following:
- Has Lp(a) ≥ 150 nmol/L
- Is receiving an optimized and stable dose of statin for ≥ 30 days with no planned additions, dose changes, or discontinuations through the duration...
You likely can't join if
- The main exclusion criteria include but are not limited to the following:
- Has a history of homozygous familial hypercholesterolemia (FH), compound heterozygous FH, or double heterozygous FH
- Has a history of class IV heart failure, severe ventricular systolic dysfunction, uncontrolled ventricular arrhythmia, markedly prolonged corrected...
- Has human immunodeficiency virus infection, unless the infection is controlled (i.e. undetectable viral load)
- Has an active hepatitis C virus infection or active or chronic hepatitis B virus infection
- Has a history of nephrotic syndrome
See the full eligibility criteria
- The main include but are not limited to the following:
- Has Lp(a) ≥ 150 nmol/L
- Is receiving an optimized and stable dose of statin for ≥ 30 days with no planned additions, dose changes, or discontinuations through the duration of the study
- The main exclusion criteria include but are not limited to the following:
- Has a history of homozygous familial hypercholesterolemia (FH), compound heterozygous FH, or double heterozygous FH
- Has a history of class IV heart failure, severe ventricular systolic dysfunction, uncontrolled ventricular arrhythmia, markedly prolonged corrected QT interval, untreated hypertension, or a recent coronary...
- Has human immunodeficiency virus infection, unless the infection is controlled (i.e. undetectable viral load)
- Has an active hepatitis C virus infection or active or chronic hepatitis B virus infection
- Has a history of nephrotic syndrome
- Has severe renal insufficiency
- Has received certain therapies in the prohibited timeframe as specified in the protocol
- Has active or chronic hepatobiliary or hepatic disease
- Has poorly controlled Type 1 or Type 2 diabetes
The study team makes the final eligibility decision.
Where it's taking place
- Alexander City, Alabama, United States
- Mobile, Alabama, United States
- Beverly Hills, California, United States
- Lincoln, California, United States
- Waterbury, Connecticut, United States
- Miami Lakes, Florida, United States
- Tampa, Florida, United States
- Winter Park, Florida, United States
- Albuquerque, New Mexico, United States
- Columbus, Ohio, United States
- Kingsport, Tennessee, United States
- Manassas, Virginia, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Alexander City, Alabama, United States; Mobile, Alabama, United States; Beverly Hills, California, United States; Lincoln, California, United States; Waterbury, Connecticut, United States; Miami Lakes, Florida, United States and 6 more location(s). Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.