BridgeMD
New treatment option for Multiple Sclerosis
Official title Silodosin for Urinary Symptoms in Female Patients With Multiple Sclerosis
ClinicalTrials.gov ID: NCT07614321
What this study is testing
What is Silodosin 8 mg?
Silodosin 8 mg is an investigational medicine, being studied as a potential treatment for multiple sclerosis.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The goal of this clinical trial is to learn if silodosin works to treat lower urinary tract symptoms (LUTS) in female patients with multiple sclerosis (MS). It will also learn about the effect of the drug on voiding parameters.
- Phase 4: studies an already-approved treatment
- You might receive a placebo (an inactive treatment) instead of the study drug.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older, women only
You may be able to join if
- Female patients with a diagnosis of multiple sclerosis
- Age \> 18
- Moderate to severe lower urinary tract symptoms as defined by an AUASS score \> 8
- No UTI
You likely can't join if
- Treatment with alpha-blocker, B3 agonist, or anticholinergic medication within the last 6 weeks
- Treatment with sacral neuromodulation, bladder Botox, or posterior tibial nerve stimulation within the last 9 months
- Renal impairment with CrCl \< 30
- PVR \> 300
- Diagnosed orthostatic hypotension
- Pregnancy or breastfeeding
See the full eligibility criteria
- Female patients with a diagnosis of multiple sclerosis
- Age \> 18
- Moderate to severe lower urinary tract symptoms as defined by an AUASS score \> 8
- No UTI
- Treatment with alpha-blocker, B3 agonist, or anticholinergic medication within the last 6 weeks
- Treatment with sacral neuromodulation, bladder Botox, or posterior tibial nerve stimulation within the last 9 months
- Renal impairment with CrCl \< 30
- PVR \> 300
- Diagnosed orthostatic hypotension
- Pregnancy or breastfeeding
- Severe liver impairment (Child-Pugh class C)
- Current symptomatic kidney stones
- Recent MS relapse within the last 3 months
- Recent treatment with steroids in the last 3 months (this does not include one-time pre-treatment with steroids for administration of immunologic drug)
The study team makes the final eligibility decision.
Where it's taking place
- Morristown, New Jersey, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling female, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Morristown, New Jersey, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.