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Tests treatment safety and results for Hypertriglyceridemia
Official title A Study to Assess the Safety, Tolerability and Efficacy of ION775
ClinicalTrials.gov ID: NCT07604974
What this study is testing
What is ION775?
ION775 is an investigational medicine, given as an injection under the skin, being studied as a potential treatment for hypertriglyceridemia.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The main objective of this study is to evaluate the effect of ION775 on fasting triglyceride (TG) levels in participants with hypertriglyceridemia (HTG) and severe hypertriglyceridemia (sHTG).
- Phase 2: a mid-size study of how well it works
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Adult males and females with HTG (fasting TG more than or equal to (≥) 350 milligrams per deciliter (mg/dL) [3.95 millimoles per liter (mmol/L)] or...
- Participants should be on standard of care lipid-lowering medications per local guidelines. Key
You likely can't join if
- Hemoglobin A1c (HbA1c) ≥ 8.5% at Screening.
- Alanine aminotransferase or aspartate aminotransferase \> 2.0 × upper limit of normal.
- Total bilirubin \> 1.5 upper limit of normal unless due to Gilbert's syndrome.
- Estimated GFR \< 30 mL/min/1.73 m\^2. Note: Other protocol pre-specified inclusion/exclusion criteria may apply.
The study team makes the final eligibility decision.
Where it's taking place
- Lincoln, California, United States
- Aurora, Colorado, United States
- Boca Raton, Florida, United States
- Miami, Florida, United States
- Miramar, Florida, United States
- Columbus, Georgia, United States
- Louisville, Kentucky, United States
- Flint, Michigan, United States
- Munroe Falls, Ohio, United States
- Little River, South Carolina, United States
- Houston, Texas, United States
- Lampasas, Texas, United States
- McKinney, Texas, United States
- Mesquite, Texas, United States
- San Antonio, Texas, United States
- Québec, Canada
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Lincoln, California, United States; Aurora, Colorado, United States; Boca Raton, Florida, United States; Miami, Florida, United States; Miramar, Florida, United States; Columbus, Georgia, United States and 10 more location(s). Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.