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New treatment option for Overweight
Official title A Study to Investigate Weight Management With Macupatide and Eloralintide, Alone or in Combination, in Adult Participants With Obesity or Overweight
ClinicalTrials.gov ID: NCT07589608
What this study is testing
What is Macupatide?
Macupatide is an investigational medicine, given as an injection under the skin, being studied as a potential treatment for overweight.
Also referred to as LY3532226.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The main purpose of this study, performed under the master protocol W8M-MC-CWMM (NCT06143956), is to examine the body weight-lowering efficacy and safety of macupatide plus eloralintide compared with placebo in participants with obesity or overweight and without type 2 diabetes. Participation will last about 64 weeks.
- Phase 2: a mid-size study of how well it works
- You might receive a placebo (an inactive treatment) instead of the study drug.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 75
You may be able to join if
- See Master Protocol CWMM (NCT06143956) for
You likely can't join if
- In addition to exclusion criteria in Master Protocol CWMM (NCT06143956):
- Have type 1 diabetes or type 2 diabetes
- Have an ongoing history of bradyarrhythmia and/or sinus bradycardia
- Have an elevated resting pulse rate (greater than 100 bpm) or reduced resting pulse rate (less than 60 bpm)
- Have a history of acute or chronic pancreatitis
- All concomitant medications should be at a stable dose for at least 3 months prior to screening
The study team makes the final eligibility decision.
Where it's taking place
- Chandler, Arizona, United States
- Scottsdale, Arizona, United States
- Tucson, Arizona, United States
- Greenbrae, California, United States
- Huntington Park, California, United States
- Rolling Hills Estates, California, United States
- Walnut Creek, California, United States
- Stamford, Connecticut, United States
- Miami, Florida, United States
- Miami Lakes, Florida, United States
- New Port Richey, Florida, United States
- Orlando, Florida, United States
- The Villages, Florida, United States
- Ammon, Idaho, United States
- Chicago, Illinois, United States
- Topeka, Kansas, United States
- Louisville, Kentucky, United States
- Needham, Massachusetts, United States
- New Bedford, Massachusetts, United States
- Southfield, Michigan, United States
+ 20 more site(s).
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 75 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Chandler, Arizona, United States; Scottsdale, Arizona, United States; Tucson, Arizona, United States; Greenbrae, California, United States; Huntington Park, California, United States; Rolling Hills Estates, California, United States and 34 more location(s). Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.