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New treatment option for Diffuse Midline Glioma, H3 K27M-Mutant
Official title A Study of VRT106 in Combination With Radiotherapy in Adult Patients With Diffuse Midline Glioma / Diffuse Intrinsic Pontine Glioma
ClinicalTrials.gov ID: NCT07589257
What this study is testing
What is VRT106 for injection?
VRT106 for injection is an investigational medicine, given as an infusion into a vein, being studied as a potential treatment for diffuse midline glioma, h3 k27m-mutant.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- To Evaluate the Preliminary Efficacy and Safety/Tolerability of VRT106 Combined with Radiotherapy in Adult Patients with DMG/DIPG
- Phase 2: a mid-size study of how well it works
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 75
You may be able to join if
- Voluntary signing of the Informed Consent Form (ICF), indicating understanding of the study and willingness and ability to comply with all study...
- Male or female adults aged 18 to 75 years at the time of signing the ICF.
- Histologically or cytologically confirmed H3 K27-altered diffuse midline glioma (DMG), or a diagnosis of DIPG based on brain contrast-enhanced MRI...
- Karnofsky Performance Status (KPS) score ≥ 60.
- Expected survival time ≥ 3 months.
You likely can't join if
- Individuals with extracranial metastases.
- Presence of spinal cord tumors or evidence of leptomeningeal disease dissemination.
- Active hemorrhage detected on cranial MRI scan prior to enrollment.
- Inability to undergo cranial MRI scanning (e.g., due to contraindications or incompatible implants).
- Prior receipt of oncolytic virus therapy or other gene therapy agents.
The study team makes the final eligibility decision.
Where it's taking place
- Guangzhou, Guangdong, China
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 75 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Guangzhou, Guangdong, China. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.