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Compares treatment options for Hemorrhoidal Bleeding
Official title Rectal Arterial Embolization vs Band Ligation for the Treatment of Internal hemOrrhoidS
ClinicalTrials.gov ID: NCT07559630
What this study is testing
- What it's testing
- The purpose of this clinical trial is to compare two standard of care non-surgical treatments for hemorrhoidal bleeding: hemorrhoidal artery embolization (HAE) versus rubber band ligation (RBL). Directly comparing these two methods may help to clarify which treatment is better for controlling hemorrhoidal bleeding, reducing symptoms, and improving patients' quality of life.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 89
You may be able to join if
- Age ≥ 18 years and less than 90 years.
- Ability to provide written informed consent.
- Documented clinical history of chronic bleeding from internal hemorrhoids.
- Documented presence of Goligher grade II-III internal hemorrhoids.
- Failed conservative treatment for bleeding hemorrhoids (e.g. fiber supplementation, topical ointments and creams, dietary modifications, stool...
You likely can't join if
- Moderate loss of kidney function, defined as estimated glomerular filtration rate of less than 45 mL/min.
- Significant arterial atherosclerosis that would limit selective angiography.
- Known alternative causes of GI bleeding.
- Allergy to iodinated contrast agents.
- Active infection or malignancy.
- Pregnancy.
See the full eligibility criteria
- Age ≥ 18 years and less than 90 years.
- Ability to provide written informed consent.
- Documented clinical history of chronic bleeding from internal hemorrhoids.
- Documented presence of Goligher grade II-III internal hemorrhoids.
- Failed conservative treatment for bleeding hemorrhoids (e.g. fiber supplementation, topical ointments and creams, dietary modifications, stool softeners, warm baths).
- Able to comply with all treatments and protocol follow-up visits, in the opinion of the PI's.
- Moderate loss of kidney function, defined as estimated glomerular filtration rate of less than 45 mL/min.
- Significant arterial atherosclerosis that would limit selective angiography.
- Known alternative causes of GI bleeding.
- Allergy to iodinated contrast agents.
- Active infection or malignancy.
- Pregnancy.
- Active nicotine use within the last 12 months.
- Portal hypertension/rectal varices.
- Uncorrectable coagulopathy (INR \> 2; Platelet count \ 40 sec).
- Findings on baseline CTA that adversely affect treatment, based on PI's clinical judgment, including but not limited to stenosis, occlusion, or hypoplasia of the superior and/or middle rectal arteries.
The study team makes the final eligibility decision.
Where it's taking place
- Los Angeles, California, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 89 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Los Angeles, California, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.