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New treatment option for Type 2 Diabetes
Official title Effect of GLP-1RA on Cardiac Autonomic Neuropathy in Type 2 Diabetes
ClinicalTrials.gov ID: NCT07558863
What this study is testing
What is GLP-1 Receptor Agonists?
GLP-1 Receptor Agonists is an investigational medicine, given as an once-weekly injection under the skin, being studied as a potential treatment for type 2 diabetes.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- This study aims to investigate whether a class of diabetes medications called GLP-1 receptor agonists (GLP-1RA), specifically semaglutide or polyethylene glycol loxenatide, can improve heart-related nerve damage in people with type 2 diabetes. This heart-related nerve damage is known as diabetic cardiac autonomic neuropathy (DCAN), which can cause problems such as fast resting heart rate, low blood pressure upon standing, and in severe cases, heart attack or sudden death.
- Phase 4: studies an already-approved treatment
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 70
You may be able to join if
- Patients aged 18-70 years
- Patients with type 2 diabetes mellitus (T2DM) who meet the diagnostic guidelines
- Patient has signed the relevant informed consent form
- Being overweight or obese (BMI ≥ 24 kg/m²)
You likely can't join if
- Age \< 18 years
- Pregnant or lactating women
- Acute or chronic pancreatitis
- Recent acute complications of diabetes (e.g., diabetic ketoacidosis, hyperosmolar hyperglycemic state)
- Arrhythmia or taking medications that affect heart rate (e.g., beta-blockers, non-dihydropyridine calcium channel blockers, antiarrhythmic drugs)
- Thyroid disease
See the full eligibility criteria
- Patients aged 18-70 years
- Patients with type 2 diabetes mellitus (T2DM) who meet the diagnostic guidelines
- Patient has signed the relevant informed consent form
- Being overweight or obese (BMI ≥ 24 kg/m²)
- Age \< 18 years
- Pregnant or lactating women
- Acute or chronic pancreatitis
- Recent acute complications of diabetes (e.g., diabetic ketoacidosis, hyperosmolar hyperglycemic state)
- Arrhythmia or taking medications that affect heart rate (e.g., beta-blockers, non-dihydropyridine calcium channel blockers, antiarrhythmic drugs)
- Thyroid disease
- Severe organ dysfunction (e.g., heart, liver, kidney failure)
- Denial of informed consent
The study team makes the final eligibility decision.
Where it's taking place
- Nanjing, Jiangsu, China
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 70 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Nanjing, Jiangsu, China. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.