BridgeMD
New treatment option for PTSD
Official title Using Exercise to Enhance Fear Extinction Learning
ClinicalTrials.gov ID: NCT07548125
What this study is testing
- What it's testing
- The goal of the current project is to establish the efficacy and mechanisms of exercise-enhanced fear extinction retrieval and generalization in posttraumatic stress disorder (PTSD). Exposure therapy is the gold standard treatment for PTSD, yet is only associated with remission rates of \~55% and in clear need of improvement.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 55
You may be able to join if
- Age 18 - 55 years of age
- Currently experiencing at least 4 PTSD symptoms with at least 1 re-experiencing symptom (e.g., trauma memory intrusion, trauma nightmares, trauma...
- English speaking
- Medically healthy
You likely can't join if
- being pregnant
- having a history of light headedness or fainting during physical activity
- having a history of chest pain during physical activity
- having a bone, joint, cardiac, or other medical condition that a doctor has said may be worsened by physical activity
- responding 'Yes' to any of the seven questions on the Physical Activity Readiness Questionnaire (PAR-Q; unless they provide a doctor's note...
- percutaneous coronary intervention or acute myocardial infarction in the last 6 weeks
See the full eligibility criteria
- Age 18 - 55 years of age
- Currently experiencing at least 4 PTSD symptoms with at least 1 re-experiencing symptom (e.g., trauma memory intrusion, trauma nightmares, trauma flashbacks, intense emotional distress related to trauma, or marked...
- English speaking
- Medically healthy
- being pregnant
- having a history of light headedness or fainting during physical activity
- having a history of chest pain during physical activity
- having a bone, joint, cardiac, or other medical condition that a doctor has said may be worsened by physical activity
- responding 'Yes' to any of the seven questions on the Physical Activity Readiness Questionnaire (PAR-Q; unless they provide a doctor's note indicating that it is safe for them to engage in aerobic exercise )
- percutaneous coronary intervention or acute myocardial infarction in the last 6 weeks
- unstable arrhythmias/implanted cardiac defibrillator shocks in the last 3 months
- Internal ferromagnetic objects (such as electronic devices, surgical implants, shrapnel, etc.)
- Nonremovable dental implants, such as braces or upper permanent retainers, as these will distort the MRI images we collect (note: filings, crowns, and silver or gold teeth are OK)
- Any other condition, medication, or implant that the investigator believes would degrade image quality or render data unusable
- psychotic disorders
- Permanent makeup or tattoos with metallic dyes,
- A self-reported history of loss of consciousness (greater than 30 minutes)
- physical disabilities that prohibit task performance (such as blindness or deafness)
- Any other condition that the investigator believes might put the participant at risk
- Claustrophobia
- History of cardiovascular disease
- on-going traumatic event exposure (e.g., living with an abusive partner)
- Severe substance use disorder.
- unstable medication (changes within the past \~4 weeks)
- Acute sedatives/pain killers (e.g., benzodiazepines, Vicodin) and prescription stimulants (e.g., Adderall) would not be permitted for 6 hours prior to the study visit.
The study team makes the final eligibility decision.
Where it's taking place
- Austin, Texas, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 55 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Austin, Texas, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.