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Compares treatment options for Acute Severe Ulcerative Colitis
Official title Comparative Effectiveness of Upadacitinib vs Corticosteroids as First-Line Therapy for Acute Severe Ulcerative Colitis（UPFRONT）
ClinicalTrials.gov ID: NCT07546097
What this study is testing
What is Upadacitinib?
Upadacitinib is an investigational medicine, given as an once-weekly pill taken by mouth, being studied as a potential treatment for acute severe ulcerative colitis.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- The goal of this clinical trial is to learn comparative effectiveness and safety of Upadacitinib vs Corticosteroids as First-Line Therapy for Acute Severe Ulcerative Colitis. The main questions it aims to answer are: 1.
- Phase 4: studies an already-approved treatment
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 85
You may be able to join if
- Patients diagnosed with ASUC
- Aged 18 years or older.
- No gender restriction.
You likely can't join if
- Presence of contraindications, allergy, or intolerance to upadacitinib or glucocorticoids.
- Patients requiring immediate colectomy; diagnosis of Crohn's disease; confirmed intestinal infection; hemodynamic instability; clinically significant...
- Presence of severe underlying systemic diseases involving the heart, lungs, liver, kidneys, hematologic system, or other organ systems.
- Pregnant or breastfeeding women.
- Unwilling to participate in the clinical study.
The study team makes the final eligibility decision.
Where it's taking place
- Ankang, Shaanxi, China
- Hanzhong, Shaanxi, China
- Xi'an, Shaanxi, China
- Xianyang, Shaanxi, China
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 85 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Ankang, Shaanxi, China; Hanzhong, Shaanxi, China; Xi'an, Shaanxi, China; Xianyang, Shaanxi, China. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.