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Tests treatment safety and results for Chronic Kidney Disease stage3
Official title Feasibility, Safety and Efficacy of a Predominantly Plant-based Diet in an Asian Population With Chronic Kidney Disease
ClinicalTrials.gov ID: NCT07544524
What this study is testing
- What it's testing
- This two-year follow up, single-center, open-label, feasibility study will recruit outpatients from the Renal Medicine Clinic at Changi General Hospital. Eligible patients with Stage 3 or 4 CKD will be assigned preferencebased to either a plant-based diet intervention (intake of at least 50% protein from plant sources) with regular dietitian counselling and follow up, or a control group receiving dietitian counselling for general CKD dietary advice without information on percentage of plant-based foods.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 21 to 79
You may be able to join if
- Age 21-79 (Only adults who can give consent will be recruited. Older adults aged 80 are not included to reduce the risk of confounding due to...
- CKD stage 3-4 (baseline eGFR 15-60ml/min/1.72m2 for the past 6 months)
- Willingness to see a dietitian and follow either a standard CKD diet or a predominantly plant-based CKD diet
- On maximum tolerated dose of ACE-inhibitors (Angiotensin converting enzyme inhibitors) or ARB (Aldosterone receptor blocker) as determined by Renal...
- Able to provide informed consent
You likely can't join if
- Transplant patients (who will tend to have more variable trajectories, immunosuppression related challenges etc which may make this study less...
- Pregnant or lactating patients (who have different nutritional requirements than the standard CKD patients)
- Patients who were on any special diet for at least 1 month prior to recruitment (inclusive of
- long-term vegans or vegetarians) - excluded because they already have stable dietary habits
- Age \ /= 80 (Avoid growing children who have different nutritional requirements and advanced elderly who are more likely to have malnutrition or...
- Those who have seen a dietitian for CKD previously
See the full eligibility criteria
- Age 21-79 (Only adults who can give consent will be recruited. Older adults aged 80 are not included to reduce the risk of confounding due to age-related frailty, sarcopenia and multimorbidity. Additionally, older...
- CKD stage 3-4 (baseline eGFR 15-60ml/min/1.72m2 for the past 6 months)
- Willingness to see a dietitian and follow either a standard CKD diet or a predominantly plant-based CKD diet
- On maximum tolerated dose of ACE-inhibitors (Angiotensin converting enzyme inhibitors) or ARB (Aldosterone receptor blocker) as determined by Renal Physician in charge
- Able to provide informed consent
- Transplant patients (who will tend to have more variable trajectories, immunosuppression related challenges etc which may make this study less feasible)
- Pregnant or lactating patients (who have different nutritional requirements than the standard CKD patients)
- Patients who were on any special diet for at least 1 month prior to recruitment (inclusive of
- long-term vegans or vegetarians) - excluded because they already have stable dietary habits
- Age \ /= 80 (Avoid growing children who have different nutritional requirements and advanced elderly who are more likely to have malnutrition or sarcopenia due to other pre-existing causes)
- Those who have seen a dietitian for CKD previously
- Patients with severe ischemic heart disease, decompensated liver cirrhosis, malabsorptive diseases or malignancy
- Patients with BMI \ 40
- Patients with glomerulonephritis, genetic kidney disease or polycystic kidney disease
- Baseline serum potassium 5.0 and above
- Patients who are unable to modify their diet due to socio-economic issues.
- Exclude patients with acute kidney injury (AKI) in the past 6 months prior to study (unstable renal disease
The study team makes the final eligibility decision.
Where it's taking place
- Singapore, Singapore
Compensation & support
A stipend or compensation may be offered.
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 21 years to 79 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Singapore, Singapore. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.