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New treatment option for Neurological Disorder
Official title INdependence Through Endovascular Neuroprosthetic Technology (INTENT): an Early Feasibility Study
ClinicalTrials.gov ID: NCT07543367
What this study is testing
- What it's testing
- INdependence Through Endovascular Neuroprosthetic Technology (INTENT): an Early Feasibility Study
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 22 and older
You may be able to join if
- Able to provide informed consent to participate in the study.
- Diagnosis of ALS, with bilateral upper-limb paresis.
- ALS must be refractory to treatment and have been present for a minimum of six months.
- Aged 22 years or older.
- Life expectancy greater than 12 months post-implantation.
You likely can't join if
- Active infection or unexplained fever in the 48 hours prior to informed consent.
- Major psychiatric disorder that may adversely impact the participant's safety or study compliance, including severe depression, psychotic features...
- Diagnosis of ALS-FTD or another dementia.
- Active implanted device (e.g., deep brain stimulator, cardiac defibrillator, pacemaker, vagal nerve stimulator, spinal cord stimulator, diaphragmatic...
- Known allergy to patient-contacting materials included in the implanted device.
- Contraindication to angiographic imaging or iodine contrast media.
See the full eligibility criteria
- Able to provide informed consent to participate in the study.
- Diagnosis of ALS, with bilateral upper-limb paresis.
- ALS must be refractory to treatment and have been present for a minimum of six months.
- Aged 22 years or older.
- Life expectancy greater than 12 months post-implantation.
- Preserved precentral gyrus assessed using CT.
- Suitable vascular anatomy assessed using CT venography.
- Suitable anatomy for subcutaneous pocket creation.
- Able to undergo anesthesia.
- Willing and able to comply with all investigational requirements, including clinical testing visits and training visits in the home.
- Caregiver(s) willing and able to facilitate study visits, including visits to the study site and in the home, and BCI use outside of study visits (e.g., device charging).
- Patient and caregiver fluent in English.
- Suitable home environment for BCI training.
- Active infection or unexplained fever in the 48 hours prior to informed consent.
- Major psychiatric disorder that may adversely impact the participant's safety or study compliance, including severe depression, psychotic features, personality disorder, severe emotional lability, or substance abuse.
- Diagnosis of ALS-FTD or another dementia.
- Active implanted device (e.g., deep brain stimulator, cardiac defibrillator, pacemaker, vagal nerve stimulator, spinal cord stimulator, diaphragmatic pacer, etc.).
- Known allergy to patient-contacting materials included in the implanted device.
- Contraindication to angiographic imaging or iodine contrast media.
- History of central venous sinus thrombosis.
- Recent history of new venous thromboembolic event (in the 6 months prior to implant), recurrent history of venous thromboembolic disease, or hypercoagulable state.
- Contraindication to antithrombotic therapy.
- Participant is at substantially increased risk of infection, including immunocompromised status, recurrent or chronic infection, or poorly controlled diabetes mellitus.
- Significant risk of non-healing of the subcutaneous pocket incision, including history of chronic non-healing surgical wounds or poorly controlled diabetes mellitus.
- Pregnant or breast feeding.
- Patients who are currently enrolled in any other clinical trial that would confound interpretation of safety or how well it works data or may interfere with the ability to meet study requirements.
- Any other disease or disorder that could significantly affect participation in the study. Examples may include corrected vision insufficient for viewing computer screens or hearing insufficient for following verbal...
The study team makes the final eligibility decision.
Where it's taking place
- Jacksonville, Florida, United States
- Buffalo, New York, United States
- New York, New York, United States
- Pittsburgh, Pennsylvania, United States
- Dallas, Texas, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 22 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Jacksonville, Florida, United States; Buffalo, New York, United States; New York, New York, United States; Pittsburgh, Pennsylvania, United States; Dallas, Texas, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.