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Compares treatment options for High-altitude Pulmonary Edema
Official title High-flow Nasal Cannula Oxygen Therapy Versus Conventional Oxygen Therapy in High-altitude Pulmonary Edema
ClinicalTrials.gov ID: NCT07536477
What this study is testing
- What it's testing
- This study aims to evaluate whether High-flow Nasal Cannula Oxygen Therapy (HFNC) provides superior respiratory support compared to Conventional Oxygen Therapy (COT) in patients with High-Altitude Pulmonary Edema (HAPE).
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Aged 18 years or older;
- Onset of symptoms related to HAPE (including dyspnea at rest, cough, or exercise intolerance) within 7 days of ascending to high altitude (≥2500m);
- Diagnosis of HAPE according to the STAR data reporting guidelines, requiring at least two symptoms (dyspnea at rest, cough, weakness/decreased...
- Radiographic evidence of pulmonary edema on chest X-ray or CT;
- Refusal or inability to undergo immediate descent at the time of presentation;
You likely can't join if
- Known or clinically confirmed pregnancy;
- Requirement for emergency intubation (as assessed by the treating clinician) due to cardiac/respiratory arrest, hemodynamic instability, airway...
- Pulmonary edema or hypoxemia resulting from other medical conditions (e.g., cardiogenic pulmonary edema, sepsis, chronic obstructive pulmonary...
- Glasgow Coma Scale (GCS) score ≤ 12;
- PaCO₂ \> 55 mmHg;
- Presence of high-altitude cerebral edema;
See the full eligibility criteria
- Aged 18 years or older;
- Onset of symptoms related to HAPE (including dyspnea at rest, cough, or exercise intolerance) within 7 days of ascending to high altitude (≥2500m);
- Diagnosis of HAPE according to the STAR data reporting guidelines, requiring at least two symptoms (dyspnea at rest, cough, weakness/decreased exercise performance, or chest tightness/congestion) and two clinical signs...
- Radiographic evidence of pulmonary edema on chest X-ray or CT;
- Refusal or inability to undergo immediate descent at the time of presentation;
- Capability and willingness to provide written informed consent.
- Known or clinically confirmed pregnancy;
- Requirement for emergency intubation (as assessed by the treating clinician) due to cardiac/respiratory arrest, hemodynamic instability, airway compromise, severe hypoxia, or impaired consciousness, etc;
- Pulmonary edema or hypoxemia resulting from other medical conditions (e.g., cardiogenic pulmonary edema, sepsis, chronic obstructive pulmonary disease (COPD), pneumothorax, massive pleural effusion, chest trauma, etc.);
- Glasgow Coma Scale (GCS) score ≤ 12;
- PaCO₂ \> 55 mmHg;
- Presence of high-altitude cerebral edema;
- Receipt of any respiratory support therapy (other than conventional oxygen therapy) prior to admission;
- Presence of any contraindication to conventional or nasal oxygen therapy;
- Presence of severe medical conditions or abnormal clinical laboratory findings that, in the investigator's judgment, may pose a risk to the patient's safety or interfere with the study's execution and participant...
- Current participation in other clinical trials;
- Refusal to sign the informed consent form.
The study team makes the final eligibility decision.
Where it's taking place
- Xigazê, Tibet, China
Compensation & support
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Xigazê, Tibet, China. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.