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Tests treatment safety and results for Severe Asthma
Official title A Phase 2 Clinical Study to Evaluate the Efficacy and Safety of Frevecitinib (KN-002) in Patients With Severe Asthma
ClinicalTrials.gov ID: NCT07532265
What this study is testing
What is Frevecitinib?
Frevecitinib is an investigational medicine, given as an inhaled treatment, being studied as a potential treatment for severe asthma.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- A Phase 2 Dose Ranging Study to Evaluate the Efficacy and Safety of Frevecitinib (KN-002) Over a 12-Week Treatment Period in Patients With Severe Asthma Not Controlled With Medium to High Dose ICS/LABA
- Phase 2: a mid-size study of how well it works
- You might receive a placebo (an inactive treatment) instead of the study drug, decided by chance. You may not know which one you got.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 to 75
You may be able to join if
- Capable of understanding the written informed consent, provides signed and witnessed written informed consent prior to any study-related procedures...
- Body mass index between 18 to 40 kg/m2 and weight ≥40 kg at screening.
- Documented physician-diagnosed asthma for at least 12 months prior to screening.
- Has received a physician-prescribed asthma controller regimen with medium dose or high dose ICS plus LABA, with or without additional controller...
- Has a pre-bronchodilator FEV1 value of ≥40% and ≤80%, predicted, at screening and at Day 1.
You likely can't join if
- Current smokers or participants with a smoking history of ≥10 pack years
- Participants with a current history of angina or history of myocardial infarction, stroke, or TIAs within the past 12 months from screening are...
- Participants with a history of pulmonary embolic or thrombotic events, or genetic or autoimmune (eg anti-phospholipid syndrome) predisposition for...
- Any concomitant respiratory disease that, in the opinion of the investigator and/or medical monitor, will interfere with the evaluation of the...
- Any clinically relevant abnormal findings in hematology, clinical chemistry, coagulation, or urinalysis (laboratory results from visit), physical...
- Evidence of active liver disease including jaundice or AST, ALT, or bilirubin greater than twice the upper limit of normal.
See the full eligibility criteria
Who can join
- Capable of understanding the written informed consent, provides signed and witnessed written informed consent prior to any study-related procedures, and agrees to comply with protocol requirements.
- Body mass index between 18 to 40 kg/m2 and weight ≥40 kg at screening.
- Documented physician-diagnosed asthma for at least 12 months prior to screening.
- Has received a physician-prescribed asthma controller regimen with medium dose or high dose ICS plus LABA, with or without additional controller medications for at least 6 months prior to screening and the dose of ICS...
- Has a pre-bronchodilator FEV1 value of ≥40% and ≤80%, predicted, at screening and at Day 1.
- Has a post-bronchodilator reversibility of FEV1 ≥12% and ≥200 mL documented during screening (15 to 30 min after administration of 4 puffs of albuterol/salbutamol).
- Has an ACQ-6 score of ≥1.5 during screening (ie, Visit 1 and Visit 2).
- Has a documented history of at least 1 asthma exacerbation in the 12 months prior to the screening visit, while using medium to high dose ICS/LABA therapy
- Acceptable inhaler, peak flow meter, and spirometry techniques during the screening/run-in period.
- ≥80% compliance with required use of the ePRO device within the last 14 days of the screening/run-in period.
- Females of childbearing potential who are sexually active with a non-sterilized male partner must use a highly effective method of contraception from the time informed consent is obtained and must agree to continue...
What rules you out
- Current smokers or participants with a smoking history of ≥10 pack years
- Participants with a current history of angina or history of myocardial infarction, stroke, or TIAs within the past 12 months from screening are disallowed.
- Participants with a history of pulmonary embolic or thrombotic events, or genetic or autoimmune (eg anti-phospholipid syndrome) predisposition for thrombosis are disallowed.
- Any concomitant respiratory disease that, in the opinion of the investigator and/or medical monitor, will interfere with the evaluation of the investigational product or interpretation of participant safety or study...
- Any clinically relevant abnormal findings in hematology, clinical chemistry, coagulation, or urinalysis (laboratory results from visit), physical examination, vital signs during the screening/run-in period which, in the...
- Evidence of active liver disease including jaundice or AST, ALT, or bilirubin greater than twice the upper limit of normal.
- History of cancer
- Participants with a respiratory tract infection that has not fully resolved by screening, or who experience an RTI during screening or at Day 1.
- Evidence of a clinically significant infection or receiving treatment with systemic antibiotic, anti-parasitic, or antiviral medications at Day 1.
- Known history of active TB or a positive QFT-G test for TB during screening.
- A positive hepatitis B surface antigen, or hepatitis C virus antibody serology at screening, or a positive medical history for hepatitis B or C.
- A positive human immunodeficiency virus test at screening or participant taking antiretroviral medications, as determined by medical history and/or participants verbal report.
- History of sensitivity to any component of the investigational product formulation or a history of drug or other allergy that, in the opinion of the investigator or medical monitor contraindicates their participation.
- Use of oral or topical JAK inhibitors for any reason or use of immunosuppressive medication (eg, methotrexate, troleandomycin, oral gold, cyclosporine, azathioprine, intramuscular long-acting depot glucocorticoid, or...
- Receipt of any investigational nonbiologic agent within 30 days or 5 half-lives prior to screening, whichever is longer and throughout the study.
- Prescription of regular daily oral corticosteroids within 4 weeks prior to screening or during the screening/run-in period and throughout the study.
- Systemic glucocorticoid burst including taper within 15 days prior to screening or during the screening/run-in period and throughout the study.
- Prescription of concomitant parenteral monoclonal antibody therapy for the management of asthma or any other condition within a specified period prior to the screening visit
- Pregnant, breastfeeding, or lactating females.
- History of chronic alcohol or drug abuse within 12 months prior to screening, as determined by the investigator.
- Planned surgical procedures requiring general anesthesia or in-patient status for \>1 day during the conduct of the study.
- Receipt of any live or attenuated vaccines within 15 days prior to screening.
- Participants who have undergone bronchial thermoplasty.
- Prolonged QTcF \>470 ms at screening or baseline.
The study team makes the final eligibility decision.
Where it's taking place
- Lancaster, California, United States
- San Jose, California, United States
- Brandon, Florida, United States
- Miami, Florida, United States
- Tampa, Florida, United States
- Chicago, Illinois, United States
- Kansas City, Missouri, United States
- Charlotte, North Carolina, United States
- Pittsburgh, Pennsylvania, United States
- Rock Hill, South Carolina, United States
- Dallas, Texas, United States
- Houston, Texas, United States
- San Antonio, Texas, United States
- Williamsburg, Virginia, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years to 75 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Lancaster, California, United States; San Jose, California, United States; Brandon, Florida, United States; Miami, Florida, United States; Tampa, Florida, United States; Chicago, Illinois, United States and 8 more location(s). Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.