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New treatment option for Parkinson' Disease
Official title Effects of Physical Exercise Combined With Transcranial Direct Current Stimulation in Parkinson's Disease
ClinicalTrials.gov ID: NCT07524400
What this study is testing
- What it's testing
- A controlled, blinded, and randomized clinical study will be carried out in a large sample of people with Parkinson's disease, where the combined effects of physical exercise and transcranial direct curren stimlation (tDCS) on motor function will be evaluated.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Adults. Healthy volunteers may be eligible.
You may be able to join if
- Clinical diagnosis of idiopathic Parkinson's disease, established according to the UK Parkinson's Disease Society Brain Bank Criteria.
- Ability to understand and comply with study procedures.
- Stable antiparkinsonian medication regimen prior to study participation.
You likely can't join if
- Significant cognitive impairment, defined as a score \< 23 on the Mini-Mental State Examination (MMSE).
- Below-average premorbid intelligence, defined as a score \< 40 on the Vocabulary subtest of the Wechsler Adult Intelligence Scale - Third Edition...
- Clinically significant depression, defined as a score \> 10 on the Geriatric Depression Scale (GDS-15).
- Current treatment with cholinesterase inhibitors.
- Presence of severe cardiovascular disease, including but not limited to:
- Congestive heart failure
See the full eligibility criteria
- Clinical diagnosis of idiopathic Parkinson's disease, established according to the UK Parkinson's Disease Society Brain Bank Criteria.
- Ability to understand and comply with study procedures.
- Stable antiparkinsonian medication regimen prior to study participation.
- Significant cognitive impairment, defined as a score \< 23 on the Mini-Mental State Examination (MMSE).
- Below-average premorbid intelligence, defined as a score \< 40 on the Vocabulary subtest of the Wechsler Adult Intelligence Scale - Third Edition (WAIS-III).
- Clinically significant depression, defined as a score \> 10 on the Geriatric Depression Scale (GDS-15).
- Current treatment with cholinesterase inhibitors.
- Presence of severe cardiovascular disease, including but not limited to:
- Congestive heart failure
- Ischemic heart disease
- Cardiac pacemaker
- Orthostatic hypotension
- Uncontrolled diabetes mellitus.
- History of stroke or traumatic brain injury.
- History of seizure disorder or epilepsy.
- Presence or prior implantation of a deep brain stimulation (DBS) device.
- History of major orthopedic surgery that could interfere with motor performance or gait.
- Presence of implanted electronic devices, including cardiac pacemakers, incompatible with study procedures.
The study team makes the final eligibility decision.
Where it's taking place
- Fuenlabrada, Madrid, Spain
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, not specified. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Fuenlabrada, Madrid, Spain. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.