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New treatment option for Respiratory Failure
Official title Noninvasive Technique and High Flow Nasal Oxygen in Respiratory Failure
ClinicalTrials.gov ID: NCT07521254
What this study is testing
- What it's testing
- After obtaining Institutional Ethical Committee approval of Faculty of Medicine, Minia University and written informed consent from patients or first- degree relatives, this prospective randomized non-blind comparative study will be conducted in adult intensive care unit (ICU) of Anesthesia, Intensive Care and Pain management department Minia university hospital over a period from September 2025 to April 2026. This study is designed to compare the effectiveness of two protocols of sequential use of High Flow Nasal Cannula (HFNC) and noninvasive ventilation (NIV) versus NIV alone in patients with Acute Respiratory failure (ARF) admitted to the intensive care unit (ICU).
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Age ≥18 year of both sexes. Diagnosed with Acute Respiratory Failure (ARF) defined as the combination of a PaO2/FiO2 ratio \ 30 breaths/min.
You likely can't join if
- Chronic respiratory disease
- Cardiogenic pulmonary edema
- Life-threatening arrythmias
- Hemodynamic instability requiring vasopressors
- Facial abnormalities preventing NIV or HFNC application
- Glasgow coma score of ≤ 12 points (Teasdale et al. 1974)
See the full eligibility criteria
- Age ≥18 year of both sexes. Diagnosed with Acute Respiratory Failure (ARF) defined as the combination of a PaO2/FiO2 ratio \ 30 breaths/min.
- Chronic respiratory disease
- Cardiogenic pulmonary edema
- Life-threatening arrythmias
- Hemodynamic instability requiring vasopressors
- Facial abnormalities preventing NIV or HFNC application
- Glasgow coma score of ≤ 12 points (Teasdale et al. 1974)
- Agitated patients characterized by RASS score (Richmond Agitation Sedation Scale) ≥ +2
- Patients who needed immediate endotracheal intubation
- Pregnant patients
The study team makes the final eligibility decision.
Where it's taking place
- Minya, Minya Governorate, Egypt
Compensation & support
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Minya, Minya Governorate, Egypt. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.