BridgeMD
New treatment option for Mechanical Ventilator Care
Official title Effect of Early Transition to Assisted Ventilation on 28-day Successful Extubation in Critically Ill Patients
ClinicalTrials.gov ID: NCT07519512
What this study is testing
- What it's testing
- EARLY-VENT is a multicenter, open-label, three-period cluster-randomized crossover trial designed to evaluate whether early transition from controlled to assisted ventilation improves outcomes in critically ill patients. The study will enroll approximately 1,600 adult patients across 10 ICUs who are expected to require mechanical ventilation for at least 48 hours and meet specific stability criteria (e.g., hemodynamically stable, light sedation).
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Age ≥ 18 years.
- Expected ICU stay and mechanical ventilation (MV) ≥ 48 hours.
- Currently receiving controlled ventilation mode
- No neuromuscular blocking agents in use, and sedation level RASS ≥ -3.
- P/F ≥ 150 mmHg.
You likely can't join if
- Severe end-stage irreversible respiratory, cardiac, or neurologic disease that may lead to long-term/chronic ventilator dependence or inability to...
- Expected death or transfer out of the ICU within 48 hours.
- Hemodynamic instability judged by the treating clinician.
- Pregnancy.
- Currently participating in other clinical studies related to mechanical ventilation.
- Any other condition considered unsuitable for participation by the investigator. Written informed consent not obtained.
The study team makes the final eligibility decision.
Where it's taking place
- Nanjing, Jiangsu, China
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Nanjing, Jiangsu, China. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.