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New treatment option for Obesity
Official title ASCEND-1: Lifestyle Intervention Plus Mazdutide for Weight Management
ClinicalTrials.gov ID: NCT07517042
What this study is testing
What is Mazdutide?
Mazdutide is an investigational medicine, given as an once-weekly injection under the skin, being studied as a potential treatment for obesity.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Obesity is a chronic, progressive, and relapsing disease. Although lifestyle interventions and anti-obesity medications are effective for inducing weight loss, evidence regarding their role in long-term weight maintenance after pharmacologically induced weight reduction remains limited.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Adult men or women aged 18 years or older;
- Simple obesity, defined as a body mass index (BMI) of 28.0-45.0 kg/m²;
- Able and willing to provide written informed consent.
You likely can't join if
- Active pulmonary tuberculosis, malignant tumors, human immunodeficiency virus (HIV) infection, or other serious infectious or systemic diseases;
- Severe hepatic impairment (aspartate aminotransferase [AST] or alanine aminotransferase [ALT] \>3 times the upper limit of normal), severe renal...
- Severe cardiovascular diseases, including angina pectoris, myocardial infarction, or stroke within the past 6 months;
- Severe gastrointestinal diseases, or a history of gastrointestinal resection surgery within the past year;
- Acute or chronic pancreatitis, gallbladder disease, or pancreatic injury;
- Obesity secondary to other causes, including Cushing's syndrome, primary hypothyroidism, hypothalamic obesity, or acromegaly; drug-induced obesity...
See the full eligibility criteria
- Adult men or women aged 18 years or older;
- Simple obesity, defined as a body mass index (BMI) of 28.0-45.0 kg/m²;
- Able and willing to provide written informed consent.
- Active pulmonary tuberculosis, malignant tumors, human immunodeficiency virus (HIV) infection, or other serious infectious or systemic diseases;
- Severe hepatic impairment (aspartate aminotransferase [AST] or alanine aminotransferase [ALT] \>3 times the upper limit of normal), severe renal impairment, or end-stage renal disease (estimated glomerular filtration...
- Severe cardiovascular diseases, including angina pectoris, myocardial infarction, or stroke within the past 6 months;
- Severe gastrointestinal diseases, or a history of gastrointestinal resection surgery within the past year;
- Acute or chronic pancreatitis, gallbladder disease, or pancreatic injury;
- Obesity secondary to other causes, including Cushing's syndrome, primary hypothyroidism, hypothalamic obesity, or acromegaly; drug-induced obesity, such as obesity related to the use of antipsychotic agents or...
- Current smoker or habitual smoking within the past 3 months;
- Current use of other weight-loss medications or a history of bariatric surgery;
- Previously diagnosed diabetes mellitus or current use of glucose-lowering medications;
- Pregnant or breastfeeding women, or women planning pregnancy during the study period;
- Inability to complete a 2-year follow-up due to health conditions, relocation, or other reasons;
- Any other condition deemed by the investigator to make the participant unsuitable for participation in the study.
The study team makes the final eligibility decision.
Where it's taking place
- Chongqing, Chongqing Municipality, China
- Fuzhou, Fujian, China
- Xiamen, Fujian, China
- Wuhan, Hubei, China
- Nanjing, Jiangsu, China
- Suzhou, Jiangsu, China
- Shanghai, Shanghai Municipality, China
- Luzhou, Sichuan, China
- Hangzhou, Zhejiang, China
- Wenzhou, Zhejiang, China
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Chongqing, Chongqing Municipality, China; Fuzhou, Fujian, China; Xiamen, Fujian, China; Wuhan, Hubei, China; Nanjing, Jiangsu, China; Suzhou, Jiangsu, China and 4 more location(s). Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.