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New treatment option for Lipid Metabolism
Official title Modulating Immune Responses After Consistent Lipid Exposure
ClinicalTrials.gov ID: NCT07502898
What this study is testing
- What it's testing
- Background of the study: Enhanced immune responses can lead to chronic hyperinflammation, which contributes to the development of non-communicable diseases such as type 2 diabetes and cardiovascular disease. Poor dietary habits, particularly the consumption of high-fat meals, are thought to trigger this process by increasing the concentration of triglyceride-rich lipoproteins in the bloodstream, resulting in postprandial triglyceridemia.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 40 to 70. Healthy volunteers may be eligible.
You may be able to join if
- Apparently healthy man or woman
- Age 40-70y at the time of screening
- BMI of 22-27 kg/m2
- Having a Hb value above 8.4 (men) or 7.4 (women) mmol/L
- Having veins suitable for blood sampling via a catheter cannula (judged by study nurse/ medical doctor)
You likely can't join if
- A history of cardiovascular diseases, such as a stroke or heart disease;
- Having an eating disorder;
- Having diabetes (type I or type II);
- Having used antibiotics in the past 3 months;
- Using diabetes medication;
- Using medications that may affect the study results (as assessed by the study physician);
See the full eligibility criteria
- Apparently healthy man or woman
- Age 40-70y at the time of screening
- BMI of 22-27 kg/m2
- Having a Hb value above 8.4 (men) or 7.4 (women) mmol/L
- Having veins suitable for blood sampling via a catheter cannula (judged by study nurse/ medical doctor)
- Willing to have dairy-based breakfast every day
- Having a mobile phone suitable for installing the research app
- Signed informed consent and able to adhere to the protocol
- A history of cardiovascular diseases, such as a stroke or heart disease;
- Having an eating disorder;
- Having diabetes (type I or type II);
- Having used antibiotics in the past 3 months;
- Using diabetes medication;
- Using medications that may affect the study results (as assessed by the study physician);
- Suffering from stomach or intestinal problems, such as Crohn's disease, ulcerative colitis, irritable bowel syndrome, or having undergone major digestive system surgery;
- Having known food allergies or intolerances to foods used in the study (e.g., cow's milk);
- Having an Hb level of less than 8.5 mmol/L (for men) or less than 7.5 mmol/L (for women) - to be tested during the eligibility assessment;
- Being allergic or intolerant to medical skin patches;
- Suffering from chronic or acute inflammatory diseases, such as rheumatoid arthritis or psoriatic arthritis;
- Having an autoimmune disease;
- Having thyroid problems;
- Having recently donated blood (within 2 months before the eligibility assessment) or planning to donate blood during the study period;
- Having recently participated in another medical-scientific study (within 2 months before the eligibility assessment);
- Suffering from severe kidney or liver problems or a chronic kidney or liver disease;
- Following a specific diet that may affect the results or is unsuitable for the study, such as a vegan diet;
- Using tobacco/drugs or smoking (including snus and/or vaping);
- Drinking more than 14 (for women) or 21 (for men) alcoholic drinks per week;
- Being pregnant, planning to become pregnant, or breastfeeding;
- Gained or lost more than 5 kg body weight in the past 3 months;
- Intention to lose or gain more than 5 kg during the study period;
- Intention to change exercise intensity during the study period;
- Not having a mobile phone suitable for using a research application;
- Having another serious medical condition that may interfere with participation, thus being deemed unsuitable for participation in the study as assessed by the study physician or principal investigator (e.g., displaying...
- Inability to comply with the study diet
- Inability to understand study information/communicate with staff;
- Being employed or doing an internship at the Department of Human Nutrition and Health of Wageningen University or FrieslandCampina.
The study team makes the final eligibility decision.
Where it's taking place
- Wageningen, Netherlands
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 40 years to 70 years. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Wageningen, Netherlands. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.