BridgeMD
New treatment option for Periapical Periodontitis
Official title Hyaluronic Acid in Endodontic Microsurgery
ClinicalTrials.gov ID: NCT07501585
What this study is testing
- What it's testing
- This randomized clinical trial (RCT) will evaluate the effectiveness of cross-linked hyaluronic acid as an adjunct to endodontic microsurgery in adult patients with apical periodontitis affecting maxillary or mandibular first molars. Participants previously treated with non-surgical endodontic therapy will be allocated to either endodontic microsurgery with cross-linked hyaluronic acid application (test group) or the same surgical procedure without adjunctive material (control group), with 12 months of follow-up.
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older. Healthy volunteers may be eligible.
You may be able to join if
- Written informed consent
- ≥18 years of age
- Apical peridontitis at maxillar or mandibular first molars ≥ 12 months after non-surgical endodontical treatment
- Full mouth plaque score (FMPS) and bleeding score (BoP) \< or 20%
- Periapical lesion \< or 10 mm
You likely can't join if
- Smokers of more than 10 cigarettes a day
- Allergy to hyaluronic acid
- Pregnancy or lactation
- Uncontrolled Diabetes
- Untreated periodontal conditions
- Any conditions associated with poor compliance or failure to maintain good oral hygiene
See the full eligibility criteria
- Written informed consent
- ≥18 years of age
- Apical peridontitis at maxillar or mandibular first molars ≥ 12 months after non-surgical endodontical treatment
- Full mouth plaque score (FMPS) and bleeding score (BoP) \< or 20%
- Periapical lesion \< or 10 mm
- Four-wall bone defect morphology
- Smokers of more than 10 cigarettes a day
- Allergy to hyaluronic acid
- Pregnancy or lactation
- Uncontrolled Diabetes
- Untreated periodontal conditions
- Any conditions associated with poor compliance or failure to maintain good oral hygiene
- Acute infections lesions in areas intended for surgery
- Chemotherapy and radiotherapy treatment
The study team makes the final eligibility decision.
Where it's taking place
- Moscow, Russia
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. Healthy volunteers may be eligible. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Moscow, Russia. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.