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New treatment option for Acute Heart Failure (AHF)
Official title Pulmonary Embolism in Patients With Acute Heart Failure (PEHF Study)
ClinicalTrials.gov ID: NCT07499661
What this study is testing
- What it's testing
- This study focuses on two serious and common medical conditions: heart failure and pulmonary embolism (a blood clot in the lungs). Heart failure happens when the heart cannot pump blood effectively, and it is one of the main reasons older adults are admitted to the hospital.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Adult patient (≥18 years)
- Admission to the emergency department or cardiology unit of a participating center
- Recent onset or worsening dyspnea and/or orthopnea
- Diagnosis of acute heart failure defined by recent dyspnea associated with at least one of the following:
- Bilateral pulmonary crackles on auscultation and/or peripheral edema
You likely can't join if
- Shock state suggesting cardiogenic shock and/or severe pulmonary embolism
- Severe respiratory distress at inclusion preventing appropriate positioning or performance of imaging examinations
- Evidence of acute coronary syndrome on electrocardiogram at admission
- Severe renal impairment (creatinine clearance \<30 mL/min)
- Known hypersensitivity or allergy to iodinated contrast agents
- Ongoing therapeutic anticoagulation for more than 48 hours prior to admission
See the full eligibility criteria
- Adult patient (≥18 years)
- Admission to the emergency department or cardiology unit of a participating center
- Recent onset or worsening dyspnea and/or orthopnea
- Diagnosis of acute heart failure defined by recent dyspnea associated with at least one of the following:
- Bilateral pulmonary crackles on auscultation and/or peripheral edema
- Signs of pulmonary congestion on chest X-ray or lung/cardiac ultrasound
- Elevated natriuretic peptide levels (BNP or NT-proBNP)
- Documented history of heart failure (known chronic heart failure or prior hospitalization for acute heart failure)
- Patient affiliated with or beneficiary of a social security system
- Patient able and willing to provide free, informed, and written consent
- Shock state suggesting cardiogenic shock and/or severe pulmonary embolism
- Severe respiratory distress at inclusion preventing appropriate positioning or performance of imaging examinations
- Evidence of acute coronary syndrome on electrocardiogram at admission
- Severe renal impairment (creatinine clearance \<30 mL/min)
- Known hypersensitivity or allergy to iodinated contrast agents
- Ongoing therapeutic anticoagulation for more than 48 hours prior to admission
- Hospitalization for more than 48 hours prior to inclusion
- Inability to ensure 90-day follow-up (e.g., end-of-life situation, no fixed address, patient not reachable)
- Inadequate understanding of the French language preventing proper study information and consent
- Pregnant, breastfeeding, or postpartum women
- Individuals under legal protection or other vulnerable populations, including minors and protected adults, in accordance with applicable public health regulations (Articles L.1121-5 to L.1121-8 and L.1122-1-2 of the...
The study team makes the final eligibility decision.
Where it's taking place
- Agen, France
- Angers, France
- Brest, France
- Chambray-lès-Tours, France
- Cholet, France
- Clermont-Ferrand, France
- La Tronche, France
- Lyon, France
- Poitiers, France
- Toulouse, France
Compensation & support
Compensation mentioned.
ClinicalTrials.gov doesn't provide a reliable structured field for payment or travel support - confirm details with the study team.
Questions & answers
Do participants get paid in this trial?
This study's listing includes signals that participants may be compensated or receive a stipend. Amounts vary and are set by the study team - confirm the details with them.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Agen, France; Angers, France; Brest, France; Chambray-lès-Tours, France; Cholet, France; Clermont-Ferrand, France and 4 more location(s). Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.