BridgeMD
New treatment option for Seroma
Official title Doxycycline Use in Post-Operative Seromas
ClinicalTrials.gov ID: NCT07498010
What this study is testing
What is Doxycycline?
Doxycycline is an investigational medicine, given as an injectable medicine, being studied as a potential treatment for seroma.
Plain-language explanation of the investigational treatment - it is being studied and is not an approved or proven therapy. The study team can confirm the details.
- What it's testing
- Seromas are collections of serous fluid that can develop following surgical procedures and may persist as fibrous-lined pseudocysts if not adequately treated. In orthopedic surgery, particularly after arthroplasty, seromas can impair wound healing, increase pain, and limit postoperative rehabilitation, potentially compromising patient recovery.
- Phase 2: a mid-size study of how well it works
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 18 and older
You may be able to join if
- Patient with seroma formation following orthopedic procedure
- \>18 years old
- Willing and able to provide informed consent
- Pre-operative imaging (US, CT) demonstrating seroma formation
You likely can't join if
- Pregnancy or lactation
- Age \<18 years
- Known allergy to tetracyclines
- Significant hepatic or renal dysfunction (Alanine Aminotransferase (ALT)/Aspartate Aminotransferase (AST) \>3× Upper Limit of Normal (ULN)...
- History of photosensitivity or photodermatosis
- Concurrent isotretinoin or retinoid therapy
See the full eligibility criteria
- Patient with seroma formation following orthopedic procedure
- \>18 years old
- Willing and able to provide informed consent
- Pre-operative imaging (US, CT) demonstrating seroma formation
- Pregnancy or lactation
- Age \<18 years
- Known allergy to tetracyclines
- Significant hepatic or renal dysfunction (Alanine Aminotransferase (ALT)/Aspartate Aminotransferase (AST) \>3× Upper Limit of Normal (ULN), Creatinine Clearance (CrCl \<30 mL/min)
- History of photosensitivity or photodermatosis
- Concurrent isotretinoin or retinoid therapy
- Current use of anticoagulants or immunosuppressants
- Active GI ulceration or esophageal disease
- Any condition likely to impair adherence or drug absorption (e.g., malabsorption syndromes)
The study team makes the final eligibility decision.
Where it's taking place
- Coral Gables, Florida, United States
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 18 years and older. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Coral Gables, Florida, United States. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.