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New treatment option for Late-Life Depression
Official title Effects of Specific Amino Acid Supplementation and Lifestyle Factors on Brain Ageing
ClinicalTrials.gov ID: NCT07497347
What this study is testing
- What it's testing
- The aim of this clinical trial is to investigate the effects of L-serine supplementation on cognitive decline and psychosocial functioning in older adults with late-life depression (LLD). The study will evaluate changes in depressive symptoms, neural and cognitive functioning, and will assess neurophysiological, metagenomic, and biochemical alterations associated with L-serine supplementation compared with placebo.
- You might receive a placebo (an inactive treatment) instead of the study drug.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 65 to 85
You may be able to join if
- Age 65-85 years;
- Presence of depressive symptoms, defined as a score ≥ 5 on the Geriatric Depression Scale-15 items (GDS-15) or ≥ 5 on the Patient Health...
You likely can't join if
- Diagnosis of dementia;
- Use of antibiotics or anti-inflammatory medications within the previous 8 weeks;
- Active gastrointestinal disease;
- Severe chronic medical conditions (e.g., advanced-stage cancer, severe cardiac or renal disorders, or other debilitating diseases);
- Renal dysfunction;
- Current alcohol or substance abuse;
See the full eligibility criteria
- Age 65-85 years;
- Presence of depressive symptoms, defined as a score ≥ 5 on the Geriatric Depression Scale-15 items (GDS-15) or ≥ 5 on the Patient Health Questionnaire-9 (PHQ-9).
- Diagnosis of dementia;
- Use of antibiotics or anti-inflammatory medications within the previous 8 weeks;
- Active gastrointestinal disease;
- Severe chronic medical conditions (e.g., advanced-stage cancer, severe cardiac or renal disorders, or other debilitating diseases);
- Renal dysfunction;
- Current alcohol or substance abuse;
- Major surgical procedures within the previous 6 months.
The study team makes the final eligibility decision.
Where it's taking place
- Brescia, Italy
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 65 years to 85 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Brescia, Italy. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.