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New treatment option for Obesity
Official title Effect of GLP-1 Receptor Agonists on Body Composition in Obesity: The Role of Dietary Protein Consumption in Muscle Mass Maintenance
ClinicalTrials.gov ID: NCT07495904
What this study is testing
- What it's testing
- This study investigates how weight-loss medications, specifically GLP-1 receptor agonists, affect body composition, with a special focus on preserving muscle mass in adults with obesity. While these medications are highly effective for weight loss, they can sometimes lead to an unwanted loss of valuable muscle mass (a condition that can lead to sarcopenia).
- Which group you join is decided by chance.
A plain-language read of the study's public ClinicalTrials.gov listing. The study team confirms the details.
Who can take part
Ages 30 to 65
You may be able to join if
- Adults 30-65 years old
- BMI: ≥30 kg/m²
- Signed Informed Consent
You likely can't join if
- A. Metabolic and Medical Conditions:
- Uncontrolled type 2 diabetes (HbA1c \> 9.0%)
- Known cardiovascular disease (e.g., coronary artery disease, heart failure NYHA 3-4)
- Chronic kidney disease stage 4-5 (GFR \<60 ml/min)
- Liver disease (known hepatitis, ALT ≥ 3 or total bilirubin ≥ 2 times ULN)
- Inflammatory bowel disease
See the full eligibility criteria
- Adults 30-65 years old
- BMI: ≥30 kg/m²
- Signed Informed Consent
- A. Metabolic and Medical Conditions:
- Uncontrolled type 2 diabetes (HbA1c \> 9.0%)
- Known cardiovascular disease (e.g., coronary artery disease, heart failure NYHA 3-4)
- Chronic kidney disease stage 4-5 (GFR \<60 ml/min)
- Liver disease (known hepatitis, ALT ≥ 3 or total bilirubin ≥ 2 times ULN)
- Inflammatory bowel disease
- Celiac disease
- History of pancreatitis
- Any disorder potentially causing malabsorption
- Active cancer or history of malignancy within the past 3 years
- Psychiatric disorders affecting adherence or assessment B. Medication and Supplement Use
- Chronic use of medications affecting metabolism or body composition (e.g., corticosteroids, anti-obesity drugs)
- Use of anti-inflammatory or antioxidant medications
- Use of probiotics, prebiotics, or laxatives within the last month
- Unstable medication regimen (changes within the past 3 months)
- Use of protein and creatine supplements. C. Dietary and Lifestyle Factors:
- Alcohol or substance abuse
- Engagement in intense regular physical activity D. Reproductive Status:
- Pregnancy or breastfeeding
- Pregnancy within the past 12 months
- Plans to become pregnant during the study E. Other: \- Any condition that, in the opinion of the Investigator, may interfere with participation, adherence, or the interpretation of study results.
The study team makes the final eligibility decision.
Where it's taking place
- Heraklion, Greece
Questions & answers
Do participants get paid in this trial?
This listing doesn't specify compensation. Many trials still reimburse travel or offer a stipend, so it's worth asking the study team when you connect.
Is it free to join, and do I need insurance?
Searching and applying through BridgeMD is free. In clinical trials the study-related treatment and visits are generally provided at no cost to you. You usually don't need insurance to take part - confirm specifics with the study team.
How long does this study last?
The listing doesn't state an exact length. The study team walks you through the schedule and number of visits before you decide to enroll.
Who can join this trial?
This study is enrolling all sexes, 30 years to 65 years. The study team makes the final eligibility decision.
Where is this trial taking place?
Study sites include Heraklion, Greece. Enter your location above to see the nearest site and check your eligibility.
Explore other conditions
BridgeMD is an information and trial-matching tool - not medical advice, and not the study sponsor. Details come from ClinicalTrials.gov; the study team decides eligibility.